Question

он CH, NHOCO CH CH CO.CH.CH diethyl acetamidomalonate HyNCHCOH CH CH(CH leucine Amino acids can be prepared by the reaction of khalides with dietylcetamidomalonate, followed by heating the metalkylation product i s HII The reaction to form leucine involves the following 1. Reaction of m a te with methods formen : 2. The enolate in acts as a nucleophile in a reaction with alkyl iodide to form alkylated intermediate 3. Heating in the presence of aque cid hydrolynes both these and the mide bonds, and induce decarboxylation to form Dugom the mechanisms te sheet of the dew the structure of calate si eine You do not have to comercrechewtry • You do not have to explicitly draw De ondeo is your They will . Det include con in your be used as the O AL OOO-

Answer 1

Br LO HN NH NH NaOEt, EtOH Br OEt ÖH diethyl acetamidomalonate NH2 CO2 H2N OH OH OH OH Tautomerization H2N OH