Question

You are recording from the postsynaptic neuron at a glutamatergic synapse that contains AMPA and NMDA receptors. You stimulate the presynaptic neuron and record an EPSP. You then apply ketamine to the synapse and allow enough time for it to have its effect on the synapse (several minutes). Then you stimulate the presynaptic neuron again and record the resulting EPSP. Which of the following sets of plots indicates what your results would look like? ***Note that the y-axes on the plots are not the same.

Set a Before ketamine Postsynaptic Membrane Potential With ketamine Postsynaptic Membrane Potential Membrane Potential (mv) Membrane Potential (mV) 0.00 83.33 166.67 333.33 4 16.67 500.00 0.00 83.33 166.67 333.33 4 16.67 500.00 250.00 Time (ms) 250.00 Time (ms) Postsynaptic Intracellular Calcium Concentration Postsynaptic Intracellular Calcium Concentration Calcium Concentration (M) Calcium Concentration (M) 0.00 83.33 166.67 333.33 4 16.67 500.00 250.00 Time (ms) 0.0 0.00 83.33 166.67 333.33 4 16.67 500.00 250.00 Time (ms)

Answer 1

NMDA,AMPA and kainate receptors are members of ionotropic class ofglutamate receptors .this hetrogenous group of ion channel exist as cation selective tetramers formed by hormone and hetero oligomerric assembly of subunits .set b was the answer