You are recording signals from a postsynaptic neuron that contains only one type of ionotropic receptor...
You are recording signals from a postsynaptic neuron that contains only one type of ionotropic receptor (and no other receptors of any kind). Your goal is to determine the reversal potential for this type of receptor. When you hold the membrane potential at -50 mV and activate these receptors, you observe that this causes IPSCs. Based on this information, what can you conclude about the reversal potential (Erev) for these receptors? (Assume that the ion concentrations inside and outside this neuron the same as those of typical neurons.)
a. Erev for this receptor is more positive than -50 mV
b. Erev for this receptor is more negative than -50 mV
c. Nothing can be concluded about Erev for this receptor based only on the information given
Homework Answers
ANSWER :-
- There is confusion regarding IPSC which should have been Inhibitory post synaptic potential. When IPSP occurs, there is definately a decrease in value such that the membrane potential becomes more negative and thus it will migrate to a point after which it will try to come back to its reversal potential at which there will be no net movement of any ions taking into consideration action potential is not happening.
- So, this indicates the reversal potential to be more negative than the value of (-50 mV) which may act as the resting membrane potential.
- So, option 'A' must be the most appropriate answer.
Note :- Respected Sir/Madam, for any doubts, please prefer communicating through the comment section and please provide an upvote if the answer seems satisfactory.
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like? ***Note that the y-axes on the...
IMAGE K shows single-channel recordings from an ionotropic
receptor, that were made using the cell-attached patch-clamp
configuration. All ion concentrations are as with normal neurons,
and ENa = +60 mV, EK = -80 mV, and ECl = -70 mV. In these traces,
the membrane potential is being held at -60 mV. In the top trace,
the experimenter stimulated the presynaptic neuron with no drug
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postsynaptic neurons. When they are activated by GABA, they can
have a range of effects. For the synapse you are studying in the
following questions, the effects of GABABRs are
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You are doing a series of experiments in which you are recording
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