Question

can someone read this hand writing??

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Answer 1

i.  Sedatives: Anxiolytic drugs

Anxiety- breakdown

Reduce anxiety

Then patients are anxious, maybe restless: they are stressed, confined to bed, heavily instrumented: endo-tracheal tubes, foley catheters, IVs etc.

ii. sedative drugs: (common) Benzodiazepines

Lorazepam (Ativan ): brand name

Midazolam ( versed)

Propofol (diprivan)

iii. Mechanism Brain has 100 billion neurons, that operate under the influence of multiple neurotransmitters relative to anxiety & operate:
a) Glutamate secreted by pre-synaptic terminals in sensory CNS pathways (central and mid-brain) is excitatory. it raises anxiety

b) Gamma- amino butyric acid (GABA) reduces neuron activity and opposes the effect of glutamate.