Question

Discuss the different dosing considerations for pediatric patients compared to those for adults.

Answer 1

Pediatric patients are different compared to adults when dosing is considered while administration. Some of the most important dosing consideration between both are

• The metabolic enzymes found in phase one and two are different
• Immaturity in the pediatric case is a major difference in doing consideration for absorption
• The binding nature of the drugs with protein
• The permeability of the drugs after administration
• The amount of water content in the body

Un simple the dosing is considered based on the absorption rate, distribution of the drugs and it metabolism followed by elimination . The weight and body surface are are important for pediatric case whereas in adults weight is sufficient to determine the dosing.