Question

Vital Signs Height: 5’10” Weight: 160 lbs BP: 118/76 RAS HR: 72, regular rate and rhythm...

Vital Signs

  • Height: 5’10”
  • Weight: 160 lbs
  • BP: 118/76 RAS
  • HR: 72, regular rate and rhythm

Current Medications

Toprol XL (metoprolol) 50 mg once daily
Lisinopril (Zestril) 5 mg once daily
Lasix (furosemide) 20 mg bid
K-Dur 20 mEq once daily
Coumadin (warfarin) 2.5 mg once daily
Nitroglycerine 0.4 mg prn

Lab Results

TESTS RESULT REFERENCE INTERVAL
INR 0.8 2 - 3

How would you educate the patient and his wife about the situation today? the patient is taking St. John’s Wort and Coumadin

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Answer #1

Despite taking warfarin ,INR (International normalized Ratio) is less than the reference because St John's wort causes induction of CYP enzymes .Thus the metabolism of the coumadin is increased hence its effectiveness is decreased.Thus he has to stop taking St John's wort.

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