Question

AutoSave OFF A S U wa Niacin pharmacotherapy (5 pt)-1 Home Insert Draw Design Layout References Mailings Review View Share Comments A E ALT AaBbcDdEe | AaBbCcDdEe AaBbCcDdEe Times New... - 12 v A A Aa A BI U ab X, X? AYDA E S AaBbCcDc AaBb CcDdEt AaBb Heading 1 Heading 2 Title AaBb CcDdEt Subtitle Paste E IS Normal No Spacing Subtle Emph... Styles Pane Sensitivity 1. What is the effect of niacin therapy on lipid levels? Which lipids get affected and what is the likely mechanism of action? (1 pt) 2. Describe the pathway associated with niacin binding to HM74A. (1 pts) 3. Other than the lipid-lowering effects, how can niacin decrease the risk of cardiovascular disease? Explain figure 1. (2 pts) 4. What are the side effects of niacin therapy and how can they be circumvented? (1 pts) Page 1 of 1 107 words x English (United States) O Focus - + 125%

Answer 1

What is the level 9 which the likely effed of niccin therapy on lipid lipids get affected and what is - mectanism of actions Therag with Nidän (Nicotinic cuid) is unique in that it improves all lipoprotein abnormalities. It sigro ficantly reduces low-density lipoprotein cholesterol, torglycest de and lipoprotein ca) levels, while increasing high density lipoprotein cholesterol levels Mechanism of Action: - Neacin inhibits a hormone-sensitive Lipase in adipose tissue which reduced the breakdown of triglycerides to free fatty acids, and transport of free feetty aads to lives.

L + + + + = Q.2 with a Descaibe Nicely the pathway assonated binding to M744, Anuner Nicotinic deld easily penetrates the blood brain barrier. Nicotinic acid, but not nicotinamide, specifically binds to the high. Ciffinity nicotinta acid G-proteth- coupled receptor Hom74 a / GPR log a Waose expresston is largely restricted to professional antigen presenting cells including microglia n o Nidan inhabits a hormone sensitive Ippuse in adipose tissue a hormone sensitive lipase in adipose tissue which reduce the breakdown of triglycerides to free fatty clüds and the transport of free fatty acidy to the liver

AL a 3 other than the lipic-lowering effects, how can niacin decrece the risk of condovasculas disease a Ans - Nidan (Nicotinic acid, vitamin B3) was considered a promising condidate to prevent cardiovascular disease because it is known to lower cholesterol in the blood nhach as one of the main Jisk factors. Therefore long term therapy with niaan was assumed to reduce the otsk of heast attack and stroke, What are the side effects of Niacid therapy and how can they be circumented ? Ans:- SIEN under Meid dizziness warmth, redness, or tingly feeling your skin Itching, dry skin sweating of chills Nausea, diarrhea, belching, gas. -muscle puin ley crumps sleep problems

ન Usually, these side effets subside over time and often are dose a related - Take nican with a full glass of cold or cool water since taking the medication with a hot drink may increase your oisk of side effects