Question

Say why? patients with kidney failure may develop osteomalcia

Answer 1

Ans)

Actually there is no biochemical characteristics that acceptably recognize every clients with osteomalacia.The histological explanations required to differentiate enhanced quantity quantity of osteoid because of faulty mineralization from that because of enhanced bone movement, both of which can coincide in kidney failure.

The development of osteomalacia in the kidney failure is multi fractional and which is not every time because of faulty metabolism of the vitamin D.The insufficient formation of 25-hydroxy vitamin D can happen due to nutritional deprivation or the urinary dropping in nephrotic syndrome, yet these are unusual reasons of osteomalacia in the clients on the haemodialysis therapy.

Actually it is not obvious to which degree faulty formation of calcitriol ,feature of last stage kidney failure is causally associated to the osteomalacia, in part because of unreliabilities as to, even if vitamin D take action straightly on the bone to encourage mineralization or even if its impacts are negotiated incidentally by regulating phosphate and calcium transfer at another locations.

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