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Case Study: An eight-month old is admitted with a diagnosis of severe dehydration secondary to shigella...

Case Study: An eight-month old is admitted with a diagnosis of severe dehydration secondary to shigella gastroenteritis. The child has refused to breastfeed since yesterday, has had no urine output the past twelve hours, and has a fever of 101.6 F axillary. An elevated BUN is noted on the initial labs and acute renal failure is diagnosed secondary to hypovolemia. Due to the severity of the illness, an antibiotic (Gentamicin) is started intravenously with a peak and trough ordered for the third dose. An oral antibiotic will be continued at discharge for 7 more days. Oral acetaminophen is also ordered for the fever.

  1. Initial posting is to detail the factors related to this child’s age and diagnosis from the above case study that would influence the pharmacokinetics of every medication administered.
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Answer #1

Average half life of gentamicin in a Childern 75 min

1mg/kg administration of gentamicin - produce mean peak concentration- 1.58 mug/ml

Acetaminophen - high oral bioavailability (88%) , half life 1.5-2.5 hour

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