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Patients receiving certain drugs that are metabolized by the CYP3A4 enzyme should not dark grapefruit juice because of its na

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Metabolism of drug Means the transformation of the drug to eliminate them from the body. Liver is the main organ which helps in the elimination of drugs by breaking down the pharmaceutical substances with the help of some enzymes. If there is any defect or inhibition in the metabolism of drugs, it cause drug toxicity because failure in metabolism leads to increased availability of drug in the blood.

As the intake of grape juice inhibit the CYP 344 enzyme action, it impair the drug metabolism leading to drug toxicity.

Thus the answer is B. Impaired metabolism and possible drug toxicity.

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