Question

Patients receiving certain drugs that are metabolized by the (19344 enzyme shoud not drrik grapefruit juice because to os chatry fees on that system. While performing client teaching the nurse's statements are based on knowledge that the efect cold benta? A Liver damage because the CYP3A4 enzyme destroys the ver B. Impaired metabolism and possible drug toxicity. C Lack of response because it doesnt get to the ste of action D. Lack of response because the drug will not be absorbed.

Answer 1

b.impaired metabolism and possible drug toxicity.

Grapefruit juice, is an inhibitor of the intestinal cytochrome P-450 3A4 system, which is responsible for the first-pass metabolism of many medications. Through the inhibition of this enzyme system, grapefruit juice interacts with a variety of medications, leading to elevation of their serum concentrations. Most notable are its effects on cyclosporine, some 1,4-dihydropyridine calcium antagonists, and some 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. In the case of some drugs, these increased drug concentrations have been associated with an increased frequency of dose-dependent adverse effects.