Question

s. Why does thiamin utilization increase among cancer patients? 6. A negative corelation exists between the need for thiamin and the umount of fat in the diet. Explain.

Answer 1

5. Thiamine utilization increase among cancer patient because the rate of DNA replication occur more rapidly in cancer cells so there is need of increase nucleotide

EXPLANATION

The utilization of a healthy diet rich in protein and other fundamental supplements and admission of smaller scale supplement (vitamins ) supplements brings down the likelihood of frequency of different infections. It is additionally realized that cancer cells have higher metabolic rates, rather than typical cells. The cancer cells expend glucose and different carbohydrates at a quicker rate than typical cells. Thiamine pyrophosphate (TPP), which fills in as a coenzyme for pyruvate dehydrogenase associated with glucose metabolism is required by or used in cancer cells at a higher rate, instead of ordinary cells. It has been set up that glycolysis is raised in cancer cells than in typical cells glycolysis bringing about expanded corrosive creation. Thiamine works as a coenzyme for the compound transketolase. Transketolase is engaged with the synthesis of nucleic acid ribose. A higher substance of ribose guarantees a high expansion rate in cancer cells. It was additionally shown that utilization of antithiamine mixes brought about hindrance of cell expansion of tumor cells The cancer cells use thiamine dependent enzyme for proliferation and survival

2.

Thiamine in its active or dynamic state, TPP, goes about as a coenzyme for catalysts pyruvate dehydrogenase, Transketolase and alpha ketoglutarate dehydrogenase that perform metabolism of starch. The metabolism of lipids does not require the action of thiamine. Thus, utilization of an eating routine wealthy in fats and lipids requires less thiamine than a high sugar diet for appropriate digestion. In a mouse contemplate it was exhibited that mice which were inadequate in thiamine endure better on a high fat eating regimen rather than high sugar diet . It was likewise demonstrated that the urinary yield of thiamine was more noteworthy in babies who expended high fat eating routine instead of high sugar diet

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