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2. A 60-year-old man with exertional angina complains of a rapid heart rate after taking sublingual nitroglycerin. What is th
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Nitroglycerine is used for the treatment of anginal pain. Nitroglycerin releases nitric oxide which activates guanylate cyclase. This results in an increase of cyclic GMP in smooth muscle and other tissues leading to dephosphorylation of myosin light chains, which regulate the contractile state in smooth muscle. Thus nitroglycerine relaxes the cardiac muscle and result in vasodilatation.

Drugs used to treat tachycardia and angina include beta blockers and calcium channel blockers.

Viagra is contraindicated for patients taking nitrate as it potentiate the hypotensive effect of nitrates.

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