Question

. Data reveals that the incidence of DVT increases with the use of oral contraceptives. In 1993, a genetic mutation, Factor V Leiden, was identified as a possible condition associated with DVT. These two risk factors, (OC and Factor V Leiden) interact. Please see the following incidence rates for DVT: -in women NOT on OCs and negative for the genetic mutation, the incidence of DVT = 0.8/10,000/year. -In women ON OCs but negative for the genetic mutation, the incidence of DVT = 3.0/10,000/year -In women NOT on OCs but + for the genetic mutation, the incidence of DVT= 5.7/10,000/year -In women ON OCs and + for the genetic mutation, the incidence of DVT = 28.5/10,000/year a. Construct a 2x2 table (do not need to insert the data) b. What is the absolute risk of DVT in women on OCs with a Leiden V Factor? c. What is the absolute risk of DVT in women who are not on OCs but have the Leiden V Factor?

Answer 1

Answer a. 2X2 table can be made as follows:

	Taking oral contraceptives (OCs)	Not taking oral contraceptives (OCs)
factor V Leiden mutation present
factor V Leiden mutation present

As these 2 factors interact with each other, data related to relative and attributable risk can be generated from the data given.

Answer b. the absolute risk of DVT in women on OCs with a Leiden V Factor is 28.5 women out of 10,000 who have the mutation and use OCs.

Answer c. The absolute risk of DVT in women not on OCs with a Leiden V Factor is 5.7 women out of 10,000 who have the mutation and do not use OCs.