Question

Question 1
A cattle drive originates in Oklahoma City in April, 1875 and moves through Arkansas to Memphis, TN, arriving in August and is associated with the following events:

•   The men on the drive note that “Cookie”, the cook for the drive is “out-of-sorts”. For about the first week of the cattle drive he appears to be having bowel problems. Within 24 to 48 hours over half the men on the drive begin to experience bloody diarrhea, fever and stomach cramps that last for about a week. Before the drive is over just about everyone on the drive has displayed similar symptoms.

*Name the disease they have contracted

*Describe the circumstances surrounding the origin of the outbreak

*And its mode of transmission.

Answer 1

Shigella .

The shigella bacteria attach to the lining of the intestines .They trick host cells,they lyse the phagosome ,multiply rapidly and kill the host cell,they lyse the phagosome ,multiply rapidly and kill the host cell.They produce toxins that increase secretion of water and cause cell death .

In this situation faecal shedding of cattle is the major source of infection. This caused infection to the cook and from hiim person to person transmission occured due to improper food handling and poor hygienic practices.As people with shigellosis are not allowed to prepare food for others until they have proven that they are no longer infected.

Transmission can occur by faecal -oral route,person -to-person transmission,consumption of contaminated food or water.Strictly human pathogen.Causes dysentry,one of the most common causes of diarrhea world wide.Shiga toxin contributes to the overall severity of illness inflammatory colitis and bloody diarrhea.