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Question

Question

Answer 1

Answer #1

Weight of the patient is 70kg

Hepatic intrinsic clearance = 350 ml/min

Volume of distribution = 7.75L

Free fraction in blood (fu)= 0.06

Ordered dose of drug Z is 250mg every 6hr

A. Formula for average steady state concentration = F × dose/ CL × dosing interval

F = bioavailability is 100% = 1 , for drugs given by intravenous route .

CL = hepatic clearance

Dosing interval = 6hours

Dose = 250mg

Hence , average steady state concentration = 1× 250mg / 350ml/min× 6

= 250mg÷ 350ml/min × 6

= 5mg/7 ml/min ×6

= 5mg / 42 ml/min

Answer 2

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