Question

Calculate the hepatic clearance (Umin) of the drug 5-fluorouracil (fus 90%; fex < 196; V-18 L ; t1/2 = 1 1 min.
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Answer #1

hepatic clearance of 5-flurouracil

V = 18L

t1/2 11 min

so by the end of 5 th half it will be come down to 90% and the fex will be <1%

so the time taken will be 11*5 = 55minutes

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