Question

Typical pharmacokinetic parameters of DRUG-A are F-0.02; fex < 0.1; fu 0.3; V- 0.22 L/Kg Half-life 4 hours. Drug-A is administered as a continuous IV-Infusion to a patient taking another medication that is known to induce the hepatic-metabolism of Drug-A. Therefore, the time to reach steady state will: D Increase 0 Decrease O Show little difference

Answer 1

# The correct option is B - Decrease.

It takes somewhere between 5 and 6 half-lives for a medication to reach steady state. Thus, medications with short half-lives reach steady state relatively quickly, while those with long half-lives take a long time to reach steady state.