Homework Answers
Ordered dose of Drug D is 60mg /hour
What is the average amount (mg ) in the body at steady state ?
Weight of the patient is 220 lb = 220 ×0.45 = 99kg
Half life of Drug A - 3hours
fex= 0.4
fu= 0.2
Volume of distribution - 1.5L/kg = 1.5× 99 = 148.5 L
Bioavailability - 0.01
At steady state , rate of drug administration = rate of drug elemination
Volume of distribution = drug dose / drug level in blood
= 148 .5L = 60mg/hour ÷ drug level in blood
148.5 = 60 / drug level in blood
Drug level in blood = 60/148.5 = 0.4 mg /hour
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