Question

can anyone help me solve this pharmokientics question

Part 1 of 2 12. A steady-state plasma concentration of 25 mg/L v by IV infusion to healthy volunteers (average weight, 75 kg) at a rate of 7.5 mg/kg/hr for 6 hours. Calculate the total body clearance of this drug. A. 12.5 L/hr B. 22.5 L/hr C. 42.5 L/hr D. 62.5 L/hr was measured when a drug was given Part 2 of 2 13. (A steady-state plasma concentration of 25 mg/L by IV infusion to healthy volunteers (average weight, 75 kg) at a rate of 7.5 mg/kg/hr for 6 hours). When the IV infusion was discontinued, the drug concentration decreased exponentially to 2.0 mg/mL at 9.0 hours after the start of the infusion. Calculate the was measured when a drug was given elimination half-life. A. 0.82 hrs B. 1.82 hrs C. 3.82 hrs D. 4.82 hrs

Answer 1

Given, concent sation 25m steady -state plasma iven 9nate of of nale Ka 2. Fon booly of 562-5 Ma we know tha t oncen t9 a Eion = 25Mg 2. To tal boda eanance 562.5 DA 25 mg 22-S L 13) Given concentgation of dhug af teg 6 houns /Bu se Concentration Bnep 9 hou ns of at 3/L 2

Given a ponen tially decixcases concentiaEion Dph Ehat Let assume CAS at KXe af Concentsation 6 houns AC 6a KXe 2S mg houis AE 2 mg KXe L 6a Kxe 25 2 e 2 2S -.a -O.8419 hg concentrat ion At half liFe (2.5 mg half life heach taken Let Eime 15 at 12-5 mg Kxe 8

6a Kx e at 25 - 17 e/2.5 Kxet 6a-at 2 In C2 - 2-9 - o -8419 6-6=-0 8233 E 6.8233 half life is Caken to each Time 68233- 6 O.8233 h3s