Question

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Preparation #1: Azithromycin 500 mg IV Infusion Preparation: Transfer 500-mg of azithromycin solution to an appropriate volume of D5W. Case: You receive an order for Azithromycin 500-mg IV infusion (2-mg/mL final concentration) for the treatment of Community Acquired Pneumonia (CAP). The recommended infusion time at this concentration is 3 hours. Formula: per package insert Azithromycin 500-mg Dry Powder for Injection Vial 500-mg Sterile Water for Injection (SWFI) 4.8mL* D5W IV Solution qs Total Volume • Per azithromycin 500-mg dry powder for injection label, add 4.8-mL of SWFI to achieve 100-mg/mL concentration. • D5W Injection Solution is available in package sizes: 50- mL; 100-mL; 250-mL; 500-ml; 1-L

Answer 1

1. Available drug azithromycin 500mg dry powder.

To achieve 100 mg/ ml you need to dilute it with 4.8 ml of SWFI. Then it will total become 5ml (4.8mkl SWFI and 0.2ml is powder)

1. to achieve 2mg/ml concentration the total volume will be 250ml

500mg + 250ml = 2mg/ml

2. Infusion rate for 3 hours is

I.e The infusion rate is 84ml per hour.

250ml = 3hrs = 83.33ml/hr

I.e The infusion rate is 1.4ml per minute.

84ml/hr + 60min = 1.4ml/min

a. The infusion rate is 1.4ml per minute.

1ml contains 2 mg

1.4 ml contains 2.8 mg

1.4ml x 2mg/ml = 2.8mg

Answer - 2.8mg will be administered per minute

b. The total volume you required 250ml for 2mg/ml concentration

So, Use a 250ml D5W injection solution and withdraw 5 ml of D5W and add 5 ml azithromycin solution.