Question

Azithromycin is sometimes prescribed for community acquired pneumonia as 500 mg PO on day 1 then 250 mg PO on days 2-5. You are asked to evaluate the possible maximal lung concentration of azithromycin after the final dose according to these dosing instructions in a male patient who weighs 158 lb. A report in the literature stated that azithromycin lung concentrations are 1030% of azithromycin blood concentrations. Assume azithromycin has an elimination half-life of 53 hr, an absorption half-life of 3.6 hr, and a volume of distribution of 31 L/kg. Azithromycin's oral bioavailability is 41.4%. Assume the drug doses are taken every 24 hours. What is the expected maximum azithromycin concentration in the lung after the 5th dose? Note: Assume the maximal drug concentration after the 5th dose occurs at a time (t-max value) equivalent to the time (t-max value) once steady state is achieved. Please also report your answer in units of (mcg/mL).

Answer 1

Azithromycine. what is the expected enoriu azithromycine concentration en lang aller the sth close ist day - 500mg Total= 175orog 2-5th day - 250mg @male patient weight - 1581b. - its lung concentration is 2030% => 1030x100 - 58.85% ® Elimination bald we=53brs Absorption hals lite - 3-6 hrs volume distributs = 312 leg. oral bioavailability - 41.43 preg closes are telles 24hs. 1750