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7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the...
Therapeutic concentration range for theophylline is 10-20 mg/L. 1. Calculate Theophylline steady state concentration at a...
Therapeutic concentration range for theophylline is 10-20 mg/L. 1. Calculate Theophylline steady state concentration at a constant infusion rate of 25 mg/ hr. 2. What will be infusion rate required to achieve therapeutic steady state concentration of 15 mg/L? NB • Apparent volume of distribution for theophylline is 30L/hr • Elmination rate constant is 0.1155 -hr.
can anyone help me solve this pharmokientics question Part 1 of 2 12. A steady-state plasma...
can anyone help me solve this pharmokientics question
Part 1 of 2 12. A steady-state plasma concentration of 25 mg/L v by IV infusion to healthy volunteers (average weight, 75 kg) at a rate of 7.5 mg/kg/hr for 6 hours. Calculate the total body clearance of this drug. A. 12.5 L/hr B. 22.5 L/hr C. 42.5 L/hr D. 62.5 L/hr was measured when a drug was given Part 2 of 2 13. (A steady-state plasma concentration of 25 mg/L by...
A drug has a volume of distribution of 33L and a clearance of 4.3 L/hr. A...
A drug has a volume of distribution of 33L and a clearance of 4.3 L/hr. A steady state concentration of 5 mg/L is reached with the administration of 21.5 mg/hr IV-infusion. What is the amount in the body at steady state?
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8 AND…in addition to answering each question, state 2 other questions aft...
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8
AND…in addition to answering each question, state 2 other
questions after each of these that might be asked of you by a
health professional that would call on you to do the same
calculation, or know the same concept. Give answer for these, and
show all work.
174 Chapter LEARNING QUESTIONS (1) Gentamicin has an average elimination half- life of approximately 2 hours and an apparent volume of distribution of 20%...
A drug (CL = 6 L/h, Va= 150 L) is to be administered as an IV...
A drug (CL = 6 L/h, Va= 150 L) is to be administered as an IV infusion. A steady-state plasma concentration of 1.2 mg L is desired. Calculate the following: (a) a suitable infusion rate, Rint (b) assuming it would take 4 half-lives to achieve the steady-state, how long would it take this drug to achieve this steady-state, tss (c) the value of a loading dose that would immediately achieve the desired steady-state plasma concentration of 1.2 mg/L, DL (d)...
An adult male (73 years old, 65 kg) with diabetes mellitus is placed on hemodialysis. His...
An adult male (73 years old, 65 kg) with diabetes mellitus is placed on hemodialysis. His residual creatinine clearance is <5mL/min. The patient is given tobramycin, an aminoglycoside antibiotic, at a dose, at a dose of 1 mg/kg by IV bolus injection. Tobramycin is 90% excreted unchanged in the urine, is less than 10% to plasma protein, and has elimination half-life 2.2 hours in patient with normal renal function. In this patient, tobramycin has an elimination t1/2 of 50hours during...
Can someone help break the accumulation index formula down for me with an example? I am...
Can someone help break the accumulation index formula down for me
with an example? I am working with a drug that has a 48 hour half
life, and is supposed to be taken every 48 hours in a dosage of
75mg.
aill AT&T Wi-Fi令 7:33 AM a sepia2.unil.ch 100% plasma concentration must be reached more rapidly. A higher dose can then be administered on treatment initiation, to compensate for accumulation. Accumulation index (RAC): Index reflecting the extent of drug accumulation...
I know a is .458mg/L; b is 1.977hr; c is 368mg; d is 17.35 L/hr. Co=...
I know a is .458mg/L; b is 1.977hr; c is 368mg; d is 17.35 L/hr.
Co= 7.36mg/L and ke=.347 1/hr. I need help with E and F. I'm not
sure how to calculate them.
Q1. A drug is eliminated through glomerular filtration and hepatic metabolism. It does not bind to plasma proteins. Glomerular filtration rate is normal. The drug does not undergo active renal secretion and passive or active reabsorption after renal filtration is observed. The volume of distribution is...
WM is a 23 year old female, who weighs 170 lb, and is on a drug...
WM is a 23 year old female, who weighs 170 lb, and is on a drug administered as a continuous IV infusion. The infusion rate is 29.3 mg/hr and the drug half life is 11.2 hours. The drug has a volume of distribution of 2.7 L/kg. How long will it take for the drug concentration to reach steady state? Note: Please provide your answer in units of hr
#1) While reviewing medication orders in a hospital, you encounter an order for tobramycin, an antibiotic,...
#1) While reviewing medication orders in a hospital, you encounter an order for tobramycin, an antibiotic, to be administered as intermittent intravenous infusions. Checking this order, you identify the following information: - The patient weighs 266 lbs - The physician ordered 5.2 mg/kg/day given in 6 divided doses - Each dose should be administered as an intermittent intravenous infusion - Each infusion should last 30 minutes - The technician has prepared a 150 mL small volume parenteral bag containing 9...
can anyone help me solve this pharmokientics question
Part 1 of 2 12. A steady-state plasma concentration of 25 mg/L v by IV infusion to healthy volunteers (average weight, 75 kg) at a rate of 7.5 mg/kg/hr for 6 hours. Calculate the total body clearance of this drug. A. 12.5 L/hr B. 22.5 L/hr C. 42.5 L/hr D. 62.5 L/hr was measured when a drug was given Part 2 of 2 13. (A steady-state plasma concentration of 25 mg/L by...
A drug has a volume of distribution of 33L and a clearance of 4.3 L/hr. A steady state concentration of 5 mg/L is reached with the administration of 21.5 mg/hr IV-infusion. What is the amount in the body at steady state?
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8
AND…in addition to answering each question, state 2 other
questions after each of these that might be asked of you by a
health professional that would call on you to do the same
calculation, or know the same concept. Give answer for these, and
show all work.
174 Chapter LEARNING QUESTIONS (1) Gentamicin has an average elimination half- life of approximately 2 hours and an apparent volume of distribution of 20%...
A drug (CL = 6 L/h, Va= 150 L) is to be administered as an IV infusion. A steady-state plasma concentration of 1.2 mg L is desired. Calculate the following: (a) a suitable infusion rate, Rint (b) assuming it would take 4 half-lives to achieve the steady-state, how long would it take this drug to achieve this steady-state, tss (c) the value of a loading dose that would immediately achieve the desired steady-state plasma concentration of 1.2 mg/L, DL (d)...
Can someone help break the accumulation index formula down for me
with an example? I am working with a drug that has a 48 hour half
life, and is supposed to be taken every 48 hours in a dosage of
75mg.
aill AT&T Wi-Fi令 7:33 AM a sepia2.unil.ch 100% plasma concentration must be reached more rapidly. A higher dose can then be administered on treatment initiation, to compensate for accumulation. Accumulation index (RAC): Index reflecting the extent of drug accumulation...
I know a is .458mg/L; b is 1.977hr; c is 368mg; d is 17.35 L/hr.
Co= 7.36mg/L and ke=.347 1/hr. I need help with E and F. I'm not
sure how to calculate them.
Q1. A drug is eliminated through glomerular filtration and hepatic metabolism. It does not bind to plasma proteins. Glomerular filtration rate is normal. The drug does not undergo active renal secretion and passive or active reabsorption after renal filtration is observed. The volume of distribution is...
WM is a 23 year old female, who weighs 170 lb, and is on a drug administered as a continuous IV infusion. The infusion rate is 29.3 mg/hr and the drug half life is 11.2 hours. The drug has a volume of distribution of 2.7 L/kg. How long will it take for the drug concentration to reach steady state? Note: Please provide your answer in units of hr
#1) While reviewing medication orders in a hospital, you encounter an order for tobramycin, an antibiotic, to be administered as intermittent intravenous infusions. Checking this order, you identify the following information: - The patient weighs 266 lbs - The physician ordered 5.2 mg/kg/day given in 6 divided doses - Each dose should be administered as an intermittent intravenous infusion - Each infusion should last 30 minutes - The technician has prepared a 150 mL small volume parenteral bag containing 9...
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