Volume of distribution - 33L
Clearance = 4.3 L/hr
Concentration at steady state = 5mg/ L
Infusion dose = 21.5 mg/ hr
Amount of drug = concentration at steady state in plasma × volume of distribution at steady state
= 5mg/L × 33L
= 165 mg
A drug has a volume of distribution of 33L and a clearance of 4.3 L/hr. A...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
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WM is a 23 year old female, who weighs 170 lb, and is on a drug administered as a continuous IV infusion. The infusion rate is 29.3 mg/hr and the drug half life is 11.2 hours. The drug has a volume of distribution of 2.7 L/kg. How long will it take for the drug concentration to reach steady state? Note: Please provide your answer in units of hr
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I know a is .458mg/L; b is 1.977hr; c is 368mg; d is 17.35 L/hr. Co= 7.36mg/L and ke=.347 1/hr. I need help with E and F. I'm not sure how to calculate them. Q1. A drug is eliminated through glomerular filtration and hepatic metabolism. It does not bind to plasma proteins. Glomerular filtration rate is normal. The drug does not undergo active renal secretion and passive or active reabsorption after renal filtration is observed. The volume of distribution is...