Plasma to blood concentration,=blood clearance/plasma clearance.
=3.4/4.5=0.75.
So,it's true.
Given the following data for Drug A: Plasma Clearance: 4.5 L/hr Blood Clearance: 3.4 L/hr It...
The total body clearance of drug A is 10.2 Uhr. Calculate blood clearance knowing that plasm to blood concentration ratio is 0.6 for this drug
A drug has a volume of distribution of 33L and a clearance of 4.3 L/hr. A steady state concentration of 5 mg/L is reached with the administration of 21.5 mg/hr IV-infusion. What is the amount in the body at steady state?
I know a is .458mg/L; b is 1.977hr; c is 368mg; d is 17.35 L/hr. Co= 7.36mg/L and ke=.347 1/hr. I need help with E and F. I'm not sure how to calculate them. Q1. A drug is eliminated through glomerular filtration and hepatic metabolism. It does not bind to plasma proteins. Glomerular filtration rate is normal. The drug does not undergo active renal secretion and passive or active reabsorption after renal filtration is observed. The volume of distribution is...
can anyone help me solve this pharmokientics question Part 1 of 2 12. A steady-state plasma concentration of 25 mg/L v by IV infusion to healthy volunteers (average weight, 75 kg) at a rate of 7.5 mg/kg/hr for 6 hours. Calculate the total body clearance of this drug. A. 12.5 L/hr B. 22.5 L/hr C. 42.5 L/hr D. 62.5 L/hr was measured when a drug was given Part 2 of 2 13. (A steady-state plasma concentration of 25 mg/L by...
Hepatic Clearance Practice Problems PH4330 1. Normal CL value for this drug is 0.5 L/min and elimination is via the liver. V 100 L a. Is this a low, intermediate, or high E drug? b. In CHF (congestive heart failure) patient, Q is half the normal value of 800 ml/min. What would the hepatic clearance be in the CHF patient? What would be the normal and CHF FFp values? c. 2. Given the following pharmacokinetic information for a drug: .Q...
You want to achieve a particular plasma concentration of a drug of approximately 81 mg/L in a 70 kg adult male. You know that the total volume of distribution for this drug is ~9L. What dose of drug should you give? (Choose the closest approximate value.) 5670 mg 729 mg correct 10 mg 9 mg In order to achieve the same plasma concentration of the above drug in an adult male who is obese (weighing 125 kg) but otherwise healthy,...
g plot shows the plasma concentrations resulting from the administration of two different doses of Drug-A to e same subject. Is it correct to say that one dose was double of the other? 1000.0 . 1000 10.0 1.0 0.1 10 20 30 TIME (HOUR) 40 50 60 O True O False
QUESTION 4 Predict the plasma concentration (in mg/L) of Drug-A six (6) hours following the administrtion of a 50 mg IV Bolus to a 42 year old subject. Drug A has a half-life of 6 hours and a volume of distribution of 25 liters
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
1. A pharmacokinetic evaluation of the absorption and elimination of a new drug provide the following data for time (hours) and concentration (mg/L): DATA t(hr) Conc(t) vwwww 250 mg Dose 0.0833 1.00 0.1667 1.60 Vd 42 L 0.25 2.75 0.5 3.33 0.75 3.65 17.1 mg h/L AUCPO wwww.www. 1 3.50 2 2.70 Drug t 2.5 h 4 1.6500 8 0.5000 12 0.1750 250mg IV produced a Co of 5.95 mg/L with an AUCIV of 21.46 mg h/L www.wvww. From this...