Question

QUESTION 4 Predict the plasma concentration (in mg/L) of Drug-A six (6) hours following the administrtion of a 50 mg IV Bolus to a 42 year old subject. Drug A has a half-life of 6 hours and a volume of distribution of 25 liters

Answer 1

Plasma concentration of a drug can be calculated as :

Volume of Distribution = Total Dose / Plasma Concentration

A = Amount of drug in the body

Vd =Volume of distribution

thus we can say that,

C = V_d $\div$ Total Dose

_{=25$\div$ 50}

_{=0.5 mg/L}