1. A new drug was given in a single intravenous dose of 200 mg to an...
1. A new drug was given in a single intravenous dose of 200 mg to an 80- kg adult male patient. The apparent VD is 0.8 L/kg, and the drug is eliminated by 1st order kinetics. Compute the initial drug plasma concentration.
2. A drug has an elimination half-life of 4 hours and follows first-order kinetics. If a single 600-mg dose is given to a patient by IV bolus, what percent of the dose is lost in 12 hours?
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1. A new drug was given in a single intravenous dose of 200 mg
to an...
DO NOT ANSWER QUESTION 10. I only need question 9 and 11 plz, answer all questions...
DO NOT ANSWER QUESTION 10. I only need question 9 and 11
plz, answer all questions clearly and correctly. i am begging
you
9. If the amount of drug in the body declines from 100% of the dose (IV bolus injection) to 25% of the dose in 8 hours, what is the elimination half-life for this drug? (Assume first-order kinetics.) (10) A drug has an elimination half-life of 8 hours and follows first-order elimination kinetics. If a single 600-mg dose...
An adult male (73 years old, 65 kg) with diabetes mellitus is placed on hemodialysis. His...
An adult male (73 years old, 65 kg) with diabetes mellitus is placed on hemodialysis. His residual creatinine clearance is <5mL/min. The patient is given tobramycin, an aminoglycoside antibiotic, at a dose, at a dose of 1 mg/kg by IV bolus injection. Tobramycin is 90% excreted unchanged in the urine, is less than 10% to plasma protein, and has elimination half-life 2.2 hours in patient with normal renal function. In this patient, tobramycin has an elimination t1/2 of 50hours during...
A Phase 1 clinical trial reported that drug elimination following a single intravenous bolus dose was...
A Phase 1 clinical trial reported that drug elimination following a single intravenous bolus dose was biphasic with drug concentrations described by the following equation: C(t)=163.3 (μg/L) × e-0.8066 hr-1 × t + 22.2 (μg/L) × e-0.0564 hr-1 × t Assume drug elimination occurs from both the central and peripheral compartments. What is the terminal elimination half-life of this drug? NOTE: Please provide your answer in units of hours (hr). Do not include the units in your answer.
plz, answer all questions clearly and correctly. i am begging you ex of activity? in a...
plz, answer all questions clearly and correctly. i am begging
you
ex of activity? in a single intra exactly, what 3. A new drug was given in a single intravenous dose of 200 mg to an 80-kg adult male patient. After 6 hours, the plasma drug concentration of drug was 1.5 mg/100 mL of plasma. Assum- ing that the apparent V, is 10% of body weight, compute the total amount of drug in the body fluids after 6 hours. What...
What is the single intravenous bolus dose necessary to produce a plasma drug concentration of 170...
What is the single intravenous bolus dose necessary to produce a plasma drug concentration of 170 nanograms per milliliter one hour after the injection? The answer needs to be in milligrams. A = 1,251.2 nanograms per milliliter B = 786 nanograms per milliliter Alpha = 0.6573 hr-1 Beta = 0.1339 hr-1 The reported central compartment volume of distribution is 7.4 L/kg and the patient weighs 90.1 kilograms.
A 90 kg man was administered a 0.044 mg/kg dose of lorazepam by iv bolus for...
A 90 kg man was administered a 0.044 mg/kg dose of lorazepam by iv bolus for pre-operative sedation. A plasma concentration of 0.066 mg/L resulted after the administration was complete and was 0.0165 mg/L 20 hours later. What is the VD .ke dose . 1112 the number of half-lives that have elapsed and clearance
We want to calculate the average concentration of a relatively short acting drug in a patient....
We want to calculate the average concentration of a relatively short acting drug in a patient. A bolus of the drug is given quickly via intravenous (IV) and the initial concentration of the drug in the patient is 20 mg/dL. The drug has a half-life of 2 hours. What is the average concentration of the drug in this patient's body over 5 half-lives? Assume first-order kinetics.
4. Following a single dose of Phenytoin (anti-seizure drug) its peak concentration in plasma decreased to...
4. Following a single dose of Phenytoin (anti-seizure drug) its peak concentration in plasma decreased to 14.8 mcg/ml in 6 hours. Phenytoin elimination is zero order kinetics. Determine the initial concentration of the drug if its first half-life is 17 hrs.
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8 AND…in addition to answering each question, state 2 other questions aft...
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8
AND…in addition to answering each question, state 2 other
questions after each of these that might be asked of you by a
health professional that would call on you to do the same
calculation, or know the same concept. Give answer for these, and
show all work.
174 Chapter LEARNING QUESTIONS (1) Gentamicin has an average elimination half- life of approximately 2 hours and an apparent volume of distribution of 20%...
DO NOT ANSWER QUESTION 10. I only need question 9 and 11
plz, answer all questions clearly and correctly. i am begging
you
9. If the amount of drug in the body declines from 100% of the dose (IV bolus injection) to 25% of the dose in 8 hours, what is the elimination half-life for this drug? (Assume first-order kinetics.) (10) A drug has an elimination half-life of 8 hours and follows first-order elimination kinetics. If a single 600-mg dose...
plz, answer all questions clearly and correctly. i am begging
you
ex of activity? in a single intra exactly, what 3. A new drug was given in a single intravenous dose of 200 mg to an 80-kg adult male patient. After 6 hours, the plasma drug concentration of drug was 1.5 mg/100 mL of plasma. Assum- ing that the apparent V, is 10% of body weight, compute the total amount of drug in the body fluids after 6 hours. What...
A 90 kg man was administered a 0.044 mg/kg dose of lorazepam by iv bolus for pre-operative sedation. A plasma concentration of 0.066 mg/L resulted after the administration was complete and was 0.0165 mg/L 20 hours later. What is the VD .ke dose . 1112 the number of half-lives that have elapsed and clearance
We want to calculate the average concentration of a relatively short acting drug in a patient. A bolus of the drug is given quickly via intravenous (IV) and the initial concentration of the drug in the patient is 20 mg/dL. The drug has a half-life of 2 hours. What is the average concentration of the drug in this patient's body over 5 half-lives? Assume first-order kinetics.
4. Following a single dose of Phenytoin (anti-seizure drug) its peak concentration in plasma decreased to 14.8 mcg/ml in 6 hours. Phenytoin elimination is zero order kinetics. Determine the initial concentration of the drug if its first half-life is 17 hrs.
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8
AND…in addition to answering each question, state 2 other
questions after each of these that might be asked of you by a
health professional that would call on you to do the same
calculation, or know the same concept. Give answer for these, and
show all work.
174 Chapter LEARNING QUESTIONS (1) Gentamicin has an average elimination half- life of approximately 2 hours and an apparent volume of distribution of 20%...
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