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A 90 kg man was administered a 0.044 mg/kg dose of lorazepam by iv bolus for...
1. The following table lists data from a volunteer weighing 55 kg administered a 300mg dose (IV bolus). Samples were dra...
1. The following table lists data from a volunteer weighing 55 kg administered a 300mg dose (IV bolus). Samples were drawn at the times indicated and plasma concentration of drug was measured. time(hrs) Cp (mg/L) 1 12.95 2 10.3 3 7.96 4 6.43 6 4.2 10 1.75 12 1.2 Calculate Kel from the data. Hint: y = mx + b What is the t1/2 What is the C0? What is the apparent volume of distribution Vd? What is the ClTB?
A patient receives an antimicrobial dose of 400 mg IV every 8 hours. After steady state...
A patient receives an antimicrobial dose of 400 mg IV every 8 hours. After steady state is reached, a peak level of 15 mg/L is determined; the level 4 hours after the peak is 4.5 mg/L. What dose is required to attain a peak plasma level of 35 mg/L? (Assume IV bolus drug administration.) A. 400 mg B. 800 mg 4-13. 933 mg D. 3108 mg
1. A new drug was given in a single intravenous dose of 200 mg to an...
1. A new drug was given in a single intravenous dose of 200 mg to an 80- kg adult male patient. The apparent VD is 0.8 L/kg, and the drug is eliminated by 1st order kinetics. Compute the initial drug plasma concentration. 2. A drug has an elimination half-life of 4 hours and follows first-order kinetics. If a single 600-mg dose is given to a patient by IV bolus, what percent of the dose is lost in 12 hours?
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized...
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized and administered DRUG-A (F 0.02; fe 0.03; t24 hours; Vd 1.2 L/kg) as an iv-infusion. The effective plasma concentration for Drug A is 3 ug/mL a. Calculate the infusion rate necessary to maintain a steady state plasma concentration of 3 ug/mL. b Calculate how long it will take to reach 90% of steady state c. Calculate the loading dose. 2. After three days of...
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized...
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized and administered DRUG-A (F - 0.02; fe - 0.03; t 2-4 hours; Vd- 1.2 L/kg) as an iv-infusion. The effective plasma concentration for Drug A is 3 ug/mL. a. Calculate the infusion rate necessary to maintain b. Calculate how long it will take to reach 90% of c. Calculate the loading dose. a steady state plasma concentration of 3 ug/mL steady state
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
just #29 please im confused how to set the problem up ! Exp. Der 28 A...
just #29 please im confused how to set the problem up !
Exp. Der 28 A 198 lb adult is to be treated with IV ticarcillin disodium for bacterial septicemia. What is the daily dosage range in mg CAM for this patient? 22 of the drug is administered every 4 hours, what will the per dose being? Sa Do you need to question a per dose dosage of 4g of ticarcillin every 4 hours for this patient? OLMES...PL 210H TICARCILLIN...
A patient receives an antimicrobial dose of 400 mg IV every 8 hours. After steady state is reached, a peak level of 15 mg/L is determined; the level 4 hours after the peak is 4.5 mg/L. What dose is required to attain a peak plasma level of 35 mg/L? (Assume IV bolus drug administration.) A. 400 mg B. 800 mg 4-13. 933 mg D. 3108 mg
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized and administered DRUG-A (F 0.02; fe 0.03; t24 hours; Vd 1.2 L/kg) as an iv-infusion. The effective plasma concentration for Drug A is 3 ug/mL a. Calculate the infusion rate necessary to maintain a steady state plasma concentration of 3 ug/mL. b Calculate how long it will take to reach 90% of steady state c. Calculate the loading dose. 2. After three days of...
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized and administered DRUG-A (F - 0.02; fe - 0.03; t 2-4 hours; Vd- 1.2 L/kg) as an iv-infusion. The effective plasma concentration for Drug A is 3 ug/mL. a. Calculate the infusion rate necessary to maintain b. Calculate how long it will take to reach 90% of c. Calculate the loading dose. a steady state plasma concentration of 3 ug/mL steady state
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
just #29 please im confused how to set the problem up !
Exp. Der 28 A 198 lb adult is to be treated with IV ticarcillin disodium for bacterial septicemia. What is the daily dosage range in mg CAM for this patient? 22 of the drug is administered every 4 hours, what will the per dose being? Sa Do you need to question a per dose dosage of 4g of ticarcillin every 4 hours for this patient? OLMES...PL 210H TICARCILLIN...
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