Homework Answers
400 mg will lead to 15 mg/L.
Another 400mg will lead to 30 mg/L.
We want to achieve 35 mg/L, so another 5 mg/L is needed. So,
5 * 400 / 15 = 133.33
So, total 933.3 mg is required to attain a peak plasma levels of 35 mg/L.
So, the correct answer is option C that is 933 mg.
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A patient receives an antimicrobial dose of 400 mg IV every 8 hours. After steady state...
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A 90 kg man was administered a 0.044 mg/kg dose of lorazepam by iv bolus for...
A 90 kg man was administered a 0.044 mg/kg dose of lorazepam by iv bolus for pre-operative sedation. A plasma concentration of 0.066 mg/L resulted after the administration was complete and was 0.0165 mg/L 20 hours later. What is the VD .ke dose . 1112 the number of half-lives that have elapsed and clearance
1. A new drug was given in a single intravenous dose of 200 mg to an...
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QUESTION4 A steady state concentration of 2 mg/L needs to be reached immediately in a patient....
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YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8 AND…in addition to answering each question, state 2 other questions aft...
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8
AND…in addition to answering each question, state 2 other
questions after each of these that might be asked of you by a
health professional that would call on you to do the same
calculation, or know the same concept. Give answer for these, and
show all work.
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7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the...
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14. Gentamicin is often given in IV-bolus doses of 100 mg every 8 hours to achieve...
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2. Steady State concentration 3 hours after last dose A patient receives a 1000 mg dose of an antibiotic every 6 hours by repetitive IV injection (ouch!). The drug has a Vo of 20 L and an elimination half-life of 3 hours. Ct (post ss) = xon-e-ke x e-kt
A 90 kg man was administered a 0.044 mg/kg dose of lorazepam by iv bolus for pre-operative sedation. A plasma concentration of 0.066 mg/L resulted after the administration was complete and was 0.0165 mg/L 20 hours later. What is the VD .ke dose . 1112 the number of half-lives that have elapsed and clearance
QUESTION4 A steady state concentration of 2 mg/L needs to be reached immediately in a patient. The drug has a half-ife of 12 hours and a volume of distribution of 75 L. Calculate the loading dose in mg.
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8
AND…in addition to answering each question, state 2 other
questions after each of these that might be asked of you by a
health professional that would call on you to do the same
calculation, or know the same concept. Give answer for these, and
show all work.
174 Chapter LEARNING QUESTIONS (1) Gentamicin has an average elimination half- life of approximately 2 hours and an apparent volume of distribution of 20%...
Calculation problem 4: nonlinear PK, phenytoin dosing A 70-kg patient has been taking phenytoin 250 mg per day for 4 months. His plasma drug level averaged 5 mg/L on this dose. Adjustment in dose to 500 mg per day eventually led to a new plateau level of 25 mg/L. The volume of distribution of phenytoin is 0.65 L/kg. 1) Use a graphical method to estimate the patient's Vma/F and K values. 2) Estimate a daily dose which should provide a...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
14. Gentamicin is often given in IV-bolus doses of 100 mg every 8 hours to achieve an average steady-state plasmatic concentration of 5 mg/L. The total clearance is normally 5.4 L/h in a 70 Kg-body weight person. Gentamicin is entirely eliminated by glomerular filtration. Your patient, however, is found to have a creatinine clearance one-third of normal. Your initial dosage regimen for this patient would probably be: a. 20 mg every 8 hours b. 33 mg every 8 hours c....
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