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2. Steady State concentration 3 hours after last dose A patient receives a 1000 mg dose...
A patient receives an antimicrobial dose of 400 mg IV every 8 hours. After steady state...
A patient receives an antimicrobial dose of 400 mg IV every 8 hours. After steady state is reached, a peak level of 15 mg/L is determined; the level 4 hours after the peak is 4.5 mg/L. What dose is required to attain a peak plasma level of 35 mg/L? (Assume IV bolus drug administration.) A. 400 mg B. 800 mg 4-13. 933 mg D. 3108 mg
QUESTION4 A steady state concentration of 2 mg/L needs to be reached immediately in a patient....
QUESTION4 A steady state concentration of 2 mg/L needs to be reached immediately in a patient. The drug has a half-ife of 12 hours and a volume of distribution of 75 L. Calculate the loading dose in mg.
An adult male (73 years old, 65 kg) with diabetes mellitus is placed on hemodialysis. His...
An adult male (73 years old, 65 kg) with diabetes mellitus is placed on hemodialysis. His residual creatinine clearance is <5mL/min. The patient is given tobramycin, an aminoglycoside antibiotic, at a dose, at a dose of 1 mg/kg by IV bolus injection. Tobramycin is 90% excreted unchanged in the urine, is less than 10% to plasma protein, and has elimination half-life 2.2 hours in patient with normal renal function. In this patient, tobramycin has an elimination t1/2 of 50hours during...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
1. A new drug was given in a single intravenous dose of 200 mg to an...
1. A new drug was given in a single intravenous dose of 200 mg to an 80- kg adult male patient. The apparent VD is 0.8 L/kg, and the drug is eliminated by 1st order kinetics. Compute the initial drug plasma concentration. 2. A drug has an elimination half-life of 4 hours and follows first-order kinetics. If a single 600-mg dose is given to a patient by IV bolus, what percent of the dose is lost in 12 hours?
Please show work. A 86.5 kg patient has just received a single 500 mg oral dose...
Please show work.
A 86.5 kg patient has just received a single 500 mg oral dose of an antibiotic. This antibiotic has a 90% oral bioavailability, 8.6 hour elimination half-life, and a 1.1 hour absorption half-life. The drug literature states that the population volume of distribution is 1.1 L/kg for this medication. A blood sample was collected at the maximum drug concentration and reported to be 5.916 mg/L. What is the patient-specific volume of distribution of this antibiotic in this...
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8 AND…in addition to answering each question, state 2 other questions aft...
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8
AND…in addition to answering each question, state 2 other
questions after each of these that might be asked of you by a
health professional that would call on you to do the same
calculation, or know the same concept. Give answer for these, and
show all work.
174 Chapter LEARNING QUESTIONS (1) Gentamicin has an average elimination half- life of approximately 2 hours and an apparent volume of distribution of 20%...
can anyone help me solve this pharmokientics question Part 1 of 2 12. A steady-state plasma...
can anyone help me solve this pharmokientics question
Part 1 of 2 12. A steady-state plasma concentration of 25 mg/L v by IV infusion to healthy volunteers (average weight, 75 kg) at a rate of 7.5 mg/kg/hr for 6 hours. Calculate the total body clearance of this drug. A. 12.5 L/hr B. 22.5 L/hr C. 42.5 L/hr D. 62.5 L/hr was measured when a drug was given Part 2 of 2 13. (A steady-state plasma concentration of 25 mg/L by...
3. The nurse receives a new medication order for a client to administer 300 mg of...
3. The nurse receives a new medication order for a client to administer 300 mg of medication per day in equally divided deres every hours. Ilow many milligrams of the drug should the nurse administer for each das? 1. A physician orders 500 mL of IV solution be administered over 3 hours. If the IV infusion set delivers 15 dropl ow many dron e should there administer to the client The ne is preparing to administer cefadroxil 1 g PO....
Azithromycin is sometimes prescribed for community acquired pneumonia as 500 mg PO on day 1 then...
Azithromycin is sometimes prescribed for community acquired pneumonia as 500 mg PO on day 1 then 250 mg PO on days 2-5. You are asked to evaluate the possible maximal lung concentration of azithromycin after the final dose according to these dosing instructions in a male patient who weighs 158 lb. A report in the literature stated that azithromycin lung concentrations are 1030% of azithromycin blood concentrations. Assume azithromycin has an elimination half-life of 53 hr, an absorption half-life of...
A patient receives an antimicrobial dose of 400 mg IV every 8 hours. After steady state is reached, a peak level of 15 mg/L is determined; the level 4 hours after the peak is 4.5 mg/L. What dose is required to attain a peak plasma level of 35 mg/L? (Assume IV bolus drug administration.) A. 400 mg B. 800 mg 4-13. 933 mg D. 3108 mg
QUESTION4 A steady state concentration of 2 mg/L needs to be reached immediately in a patient. The drug has a half-ife of 12 hours and a volume of distribution of 75 L. Calculate the loading dose in mg.
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
Please show work.
A 86.5 kg patient has just received a single 500 mg oral dose of an antibiotic. This antibiotic has a 90% oral bioavailability, 8.6 hour elimination half-life, and a 1.1 hour absorption half-life. The drug literature states that the population volume of distribution is 1.1 L/kg for this medication. A blood sample was collected at the maximum drug concentration and reported to be 5.916 mg/L. What is the patient-specific volume of distribution of this antibiotic in this...
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8
AND…in addition to answering each question, state 2 other
questions after each of these that might be asked of you by a
health professional that would call on you to do the same
calculation, or know the same concept. Give answer for these, and
show all work.
174 Chapter LEARNING QUESTIONS (1) Gentamicin has an average elimination half- life of approximately 2 hours and an apparent volume of distribution of 20%...
can anyone help me solve this pharmokientics question
Part 1 of 2 12. A steady-state plasma concentration of 25 mg/L v by IV infusion to healthy volunteers (average weight, 75 kg) at a rate of 7.5 mg/kg/hr for 6 hours. Calculate the total body clearance of this drug. A. 12.5 L/hr B. 22.5 L/hr C. 42.5 L/hr D. 62.5 L/hr was measured when a drug was given Part 2 of 2 13. (A steady-state plasma concentration of 25 mg/L by...
3. The nurse receives a new medication order for a client to administer 300 mg of medication per day in equally divided deres every hours. Ilow many milligrams of the drug should the nurse administer for each das? 1. A physician orders 500 mL of IV solution be administered over 3 hours. If the IV infusion set delivers 15 dropl ow many dron e should there administer to the client The ne is preparing to administer cefadroxil 1 g PO....
Azithromycin is sometimes prescribed for community acquired pneumonia as 500 mg PO on day 1 then 250 mg PO on days 2-5. You are asked to evaluate the possible maximal lung concentration of azithromycin after the final dose according to these dosing instructions in a male patient who weighs 158 lb. A report in the literature stated that azithromycin lung concentrations are 1030% of azithromycin blood concentrations. Assume azithromycin has an elimination half-life of 53 hr, an absorption half-life of...
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