Homework Answers
1.i already give answer of first question.
2.in 4 th t1/2 the drug will reach 93%steady state concentration.
T1/2=4 hoursSo.it .it is 4x4=16 hours.
So it will take approximately 15 hours to 90% Steady state concentration
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1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized...
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized...
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized and administered DRUG-A (F 0.02; fe 0.03; t24 hours; Vd 1.2 L/kg) as an iv-infusion. The effective plasma concentration for Drug A is 3 ug/mL a. Calculate the infusion rate necessary to maintain a steady state plasma concentration of 3 ug/mL. b Calculate how long it will take to reach 90% of steady state c. Calculate the loading dose. 2. After three days of...
A drug (CL = 6 L/h, Va= 150 L) is to be administered as an IV...
A drug (CL = 6 L/h, Va= 150 L) is to be administered as an IV infusion. A steady-state plasma concentration of 1.2 mg L is desired. Calculate the following: (a) a suitable infusion rate, Rint (b) assuming it would take 4 half-lives to achieve the steady-state, how long would it take this drug to achieve this steady-state, tss (c) the value of a loading dose that would immediately achieve the desired steady-state plasma concentration of 1.2 mg/L, DL (d)...
A 208 lb hospitalized patient received intermittent intravenous infusions of an antibiotic for a serious and...
A 208 lb hospitalized patient received intermittent intravenous infusions of an antibiotic for a serious and life threatening infection from a burn wound. The patient received 3.3 mg/kg infused over 20 minutes administered every 6 hours. A blood samples was collected 45 minutes before the third infusion was started and the drug concentration was found to be 16.6 mcg/mL. Another blood sample was collected 45 minutes after the third infusion was completed and the drug concentration was found to be...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
#1) While reviewing medication orders in a hospital, you encounter an order for tobramycin, an antibiotic,...
#1) While reviewing medication orders in a hospital, you encounter an order for tobramycin, an antibiotic, to be administered as intermittent intravenous infusions. Checking this order, you identify the following information: - The patient weighs 266 lbs - The physician ordered 5.2 mg/kg/day given in 6 divided doses - Each dose should be administered as an intermittent intravenous infusion - Each infusion should last 30 minutes - The technician has prepared a 150 mL small volume parenteral bag containing 9...
1. The following table lists data from a volunteer weighing 55 kg administered a 300mg dose (IV bolus). Samples were dra...
1. The following table lists data from a volunteer weighing 55 kg administered a 300mg dose (IV bolus). Samples were drawn at the times indicated and plasma concentration of drug was measured. time(hrs) Cp (mg/L) 1 12.95 2 10.3 3 7.96 4 6.43 6 4.2 10 1.75 12 1.2 Calculate Kel from the data. Hint: y = mx + b What is the t1/2 What is the C0? What is the apparent volume of distribution Vd? What is the ClTB?
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8 AND…in addition to answering each question, state 2 other questions aft...
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8
AND…in addition to answering each question, state 2 other
questions after each of these that might be asked of you by a
health professional that would call on you to do the same
calculation, or know the same concept. Give answer for these, and
show all work.
174 Chapter LEARNING QUESTIONS (1) Gentamicin has an average elimination half- life of approximately 2 hours and an apparent volume of distribution of 20%...
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized and administered DRUG-A (F 0.02; fe 0.03; t24 hours; Vd 1.2 L/kg) as an iv-infusion. The effective plasma concentration for Drug A is 3 ug/mL a. Calculate the infusion rate necessary to maintain a steady state plasma concentration of 3 ug/mL. b Calculate how long it will take to reach 90% of steady state c. Calculate the loading dose. 2. After three days of...
A drug (CL = 6 L/h, Va= 150 L) is to be administered as an IV infusion. A steady-state plasma concentration of 1.2 mg L is desired. Calculate the following: (a) a suitable infusion rate, Rint (b) assuming it would take 4 half-lives to achieve the steady-state, how long would it take this drug to achieve this steady-state, tss (c) the value of a loading dose that would immediately achieve the desired steady-state plasma concentration of 1.2 mg/L, DL (d)...
A 208 lb hospitalized patient received intermittent intravenous infusions of an antibiotic for a serious and life threatening infection from a burn wound. The patient received 3.3 mg/kg infused over 20 minutes administered every 6 hours. A blood samples was collected 45 minutes before the third infusion was started and the drug concentration was found to be 16.6 mcg/mL. Another blood sample was collected 45 minutes after the third infusion was completed and the drug concentration was found to be...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
#1) While reviewing medication orders in a hospital, you encounter an order for tobramycin, an antibiotic, to be administered as intermittent intravenous infusions. Checking this order, you identify the following information: - The patient weighs 266 lbs - The physician ordered 5.2 mg/kg/day given in 6 divided doses - Each dose should be administered as an intermittent intravenous infusion - Each infusion should last 30 minutes - The technician has prepared a 150 mL small volume parenteral bag containing 9...
YOU ONLY NEED TO ANSWER QUESTIONS 1,5, & 8
AND…in addition to answering each question, state 2 other
questions after each of these that might be asked of you by a
health professional that would call on you to do the same
calculation, or know the same concept. Give answer for these, and
show all work.
174 Chapter LEARNING QUESTIONS (1) Gentamicin has an average elimination half- life of approximately 2 hours and an apparent volume of distribution of 20%...
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