Question

A Phase 1 clinical trial reported that drug elimination following a single intravenous bolus dose was biphasic with drug concentrations described by the following equation:

C(t)=163.3 (μg/L) × e^{-0.8066 hr-1 × t} + 22.2 (μg/L) × e^{-0.0564 hr-1 × t}

Assume drug elimination occurs from both the central and peripheral compartments. What is the terminal elimination half-life of this drug?

NOTE: Please provide your answer in units of hours (hr). Do not include the units in your answer.

Answer 1

using given equation to calculate initial concnetration of drug and hence time at which concentration reaches half of initial value.

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