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4. Following a single dose of Phenytoin (anti-seizure drug) its peak concentration in plasma decreased to 14.8 mcg/ml in 6 ho

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Answer #1

Zero order kinetics means constant amount of drug is excreted per unit time.

Half life is 17 hours.

So concentration falls to14.8 mcg/ml in 6 hours.

Let's assume the initial concentration to be X.

So concentration after 17 hours = X/2

So amount excreted per hour= X/2*17 = X/34

So amount remaining after 6 hours = X - 6*X/34 = 28 X/34

28 X/34 = 14.8

X = 17.97 mcg/ml

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