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If the patient had been given one dose of procainamide resulting in a peak concentration of 22 μg/mL, what would the the...

If the patient had been given one dose of procainamide resulting in a peak concentration of 22 μg/mL, what would the theoretical blood level have been 24 hours later if no further drug was administered (half-life is 8 hours) and no other factors influenced the results?

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Answer #1

If one dose of procainamide produces a peak concentration of 22mcg /ml

Half Life of the drug is 8 hours ,means the drug procainamide takes 8hours to reduce to half of its initial value .

So, the peak concentration is 22 mcg/ml

After 8hrs ,it will be half 11mcg/ml

Then after 24hrs ,it will be 2.75mcg/ml

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