When a 120 mg IV-Bolus of Drug A is administered to a patient, an AUC -60...

Question

Question

Answer 1

Answer #1

Formula to calculate volume of distribution , Vd :

Vd = CL/KE, where CL is the clearance and KE is the elimination rate constant.

The given values are

D (dose) =120 mg

AUC (Area under curve) = 60 mg / L/hr

T1/2 ( half life ) = 12 hrs.

In(2) = 0.693 ( constant value)

Formula to calculate CL and KE

CL = D÷AUC = 120÷60 = 2

KE = In (2) ÷ t1/2 = 0.693÷12= 0.057

Vd = CL÷KE = 2÷0.057= 35 litres.

So the volume of distribution of drug A is 35 litres.

Answer 2

Similar Homework Help Questions

A 500 mg iv-bolus of drug A is administered to a subject at 8 am. The...

A 500 mg iv-bolus of drug A is administered to a subject at 8 am. The drug has a CL of 4 L/hr. What is the percentage eliminated in the first 6 hours, given an AUC0-6 hours of 25 mg/L/hr?
When 800 mg of a new drug under study is administered IV in normal volunteers, 800...

When 800 mg of a new drug under study is administered IV in normal volunteers, 800 mg are recovered unchanged in urine. The AUC obtained after IV injection is 400 mg.h/L and the half life is 8 hours. When 400 mg are orally administered in volunteers 350 mg of drug are recovered unchanged in urine. Calculate: K, Kr, Vd, and oral bioavailability (F). thats all the data i have
WK is a 60 year old female who is administered a drug via continuous IV infusion....

WK is a 60 year old female who is administered a drug via continuous IV infusion. The volume of distribution is 63 L and a half life of 16.8 hours. The drug concentration 29 hours after the infusion was started is reported to be 1.11 mg/L. What is the rate of infusion? Note: Assume the infusion is ongoing. Please provide your answer in units of mg/hr

Case 1 ( homework) A drug (200 mg) is administered to a 70-kg male patient by...

Case 1 ( homework) A drug (200 mg) is administered to a 70-kg male patient by multiple IV injections at 6-h intervals. The drug is water-soluble and has a distribution volume equivalent to that of total body water (50 liters). The drug has a biological half-life of 6 h. Calculate (Css (max), Css (min) and Cav(ss). The time necessary to reach 95% of the steady-state concentration. The number of doses required to reach 95% of the steady-state concentration.
kinteic Case 1 ( homework) A drug (200 mg) is administered to a 70-kg male patient...

kinteic Case 1 ( homework) A drug (200 mg) is administered to a 70-kg male patient by multiple IV injections at 6-h intervals. The drug is water-soluble and has a distribution volume equivalent to that of total body water (50 liters). The drug has a biological half-life of 6 h. Calculate (Css (max), Css (min) and Cav(ss). The time necessary to reach 95% of the steady-state concentration. The number of doses required to reach 95% of the steady-state concentration.
QUESTION 4 Predict the plasma concentration (in mg/L) of Drug-A six (6) hours following the administrtion...

QUESTION 4 Predict the plasma concentration (in mg/L) of Drug-A six (6) hours following the administrtion of a 50 mg IV Bolus to a 42 year old subject. Drug A has a half-life of 6 hours and a volume of distribution of 25 liters

BJ is a 70 year old female who is administered a drug via continuous IV infusion....

BJ is a 70 year old female who is administered a drug via continuous IV infusion. The volume of distribution is 51 L and a half life of 19.8 hours. The drug concentration 19 hours after the infusion was started is reported to be 0.69 mg/L. What is the rate of infusion? Note: Assume the infusion is ongoing. Please provide your answer in units of mg/hr.
EW is a 68 year old male who is administered a drug via continuous IV infusion....

EW is a 68 year old male who is administered a drug via continuous IV infusion. The volume of distribution is 56 L and a half life of 16.7 hours. The drug concentration 36 hours after the infusion was started is reported to be 1.84 mg/L. What is the rate of infusion? Note: Assume the infusion is ongoing. Please provide your answer in units of mg/hr:
A 199 lb patient is ordered to receive intermittent IV infusions of a drug. This drug...

A 199 lb patient is ordered to receive intermittent IV infusions of a drug. This drug has a population-based Vd of o. Lkg and a 6 hr elimination half-life. The ordering physician has indicated the rate of drug infusion should be 150 mg/hr for a total time of 2 hours. Assume the nurse will set the infusion pump to be 2 mL/min. You must now prepare the small volume parenteral bag containing the drug. What should be the drug concentration...

oA physician wishes to administer an anti-arrhythmic drug via multiple IV bolus doises to a patient...

oA physician wishes to administer an anti-arrhythmic drug via multiple IV bolus doises to a patient for the immediate treatment of ventricular arrhythmia. Calculate a recommended loading dose and suitable dosing regimen that would maintain a maximum and minimum steady concentration of 20 and 10 mg/L respectively for this drug. The drug has a half life of 11 hours and a VD 30 L A. What is your recommended loading dose B. What would be the appropriate dosing interval for...