Question

oA physician wishes to administer an anti-arrhythmic drug via multiple IV bolus doises to a patient for the immediate treatment of ventricular arrhythmia. Calculate a recommended loading dose and suitable dosing regimen that would maintain a maximum and minimum steady concentration of 20 and 10 mg/L respectively for this drug. The drug has a half life of 11 hours and a VD 30 L A. What is your recommended loading dose B. What would be the appropriate dosing interval for this drug C. What is the appropriate maintenance dose D. What would be the average steady state concentration:s attained with your dosing interval calculated

Answer 1

A, maximum and minimum steady concentration 20 and 10mg/l

So loading dose should be initial dose for immediate treatment

So 20mg over 5minutes

B, drug has a half life 11hours

C, maintenance dose should be reduced by one third in patient initial dose..this is to achieve the target steady-state, plasma concentration..interval that steadily exceeds their elimination half life..volume of distribution 30l

10mg/l

300mg over 11hours