WK is a 60 year old female who is administered a drug via continuous IV infusion....
BJ is a 70 year old female who is administered a drug via continuous IV infusion. The volume of distribution is 51 L and a half life of 19.8 hours. The drug concentration 19 hours after the infusion was started is reported to be 0.69 mg/L. What is the rate of infusion? Note: Assume the infusion is ongoing. Please provide your answer in units of mg/hr.
EW is a 68 year old male who is administered a drug via continuous IV infusion. The volume of distribution is 56 L and a half life of 16.7 hours. The drug concentration 36 hours after the infusion was started is reported to be 1.84 mg/L. What is the rate of infusion? Note: Assume the infusion is ongoing. Please provide your answer in units of mg/hr:
WM is a 23 year old female, who weighs 170 lb, and is on a drug administered as a continuous IV infusion. The infusion rate is 29.3 mg/hr and the drug half life is 11.2 hours. The drug has a volume of distribution of 2.7 L/kg. How long will it take for the drug concentration to reach steady state? Note: Please provide your answer in units of hr
When a 120 mg IV-Bolus of Drug A is administered to a patient, an AUC -60 mg/L/hr is observed. Knowing that Drug A has an half-life of 12 hours, calculate the volume of distribution of Drug A in liters
The antifungal drug anidulafungin is administered by IV infusion. The maximum infusion rate is achieved when 260 ml of anidulafungin solution, which has a concentration of 0.77 mg/ml, are delivered in 3 hours. What is the maximum infusion rate in milligrams per minute? A loading dose of voriconazole consists of 5 mg for every kilogram of body mass. This dose is administered as two IV infusions separated by 12 hours. The concentration of the solution is 10 mg/ml. If a...
A patient is administered a drug through IV infusion at a rate of 300 mg/h. The drug is eliminated from the body via urine and the halflife is reported as 5h. Based on the patient’s weight, you are expecting a steady-state level of 7 mg/ml. A) Based on these assumptions, how much is Vd? B) A blood test shows that the concentration of the drug in the plasma is 15 mg/ml. Looking at your assumptions, what might have been wrong?...
A 199 lb patient is ordered to receive intermittent IV infusions of a drug. This drug has a population-based Vd of o. Lkg and a 6 hr elimination half-life. The ordering physician has indicated the rate of drug infusion should be 150 mg/hr for a total time of 2 hours. Assume the nurse will set the infusion pump to be 2 mL/min. You must now prepare the small volume parenteral bag containing the drug. What should be the drug concentration...
The drug has a hal-life of 3 hours and a volume of distribution of 100 L. The drug is administered for 12 hours at 300 mg/hr rate. Calculate the plasma concentration (mg/L) 6 hours from the end of the infusion.
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
A drug (CL = 6 L/h, Va= 150 L) is to be administered as an IV infusion. A steady-state plasma concentration of 1.2 mg L is desired. Calculate the following: (a) a suitable infusion rate, Rint (b) assuming it would take 4 half-lives to achieve the steady-state, how long would it take this drug to achieve this steady-state, tss (c) the value of a loading dose that would immediately achieve the desired steady-state plasma concentration of 1.2 mg/L, DL (d)...