A patient is administered a drug through IV infusion at a rate of 300 mg/h. The...
A patient is administered a drug through IV infusion at a rate of 300 mg/h. The drug is eliminated from the body via urine and the halflife is reported as 5h. Based on the patient’s weight, you are expecting a steady-state level of 7 mg/ml.
A) Based on these assumptions, how much is Vd?
B) A blood test shows that the concentration of the drug in the plasma is 15 mg/ml. Looking at your assumptions, what might have been wrong?
C) What would you change to address this?
Homework Answers
Infusion rate of the drug = 300mg/hour
Half life = 5hours
Concentration at steady state = 7mg/ml
A. Volume of distribution = Total Dose / Concentration
= 300/ 7
= 42.8 ml
Add Answer to:
A patient is administered a drug through IV infusion at a rate
of 300 mg/h. The...
The antifungal drug anidulafungin is administered by IV infusion. The maximum infusion rate is achieved when...
The antifungal drug anidulafungin is administered by IV infusion. The maximum infusion rate is achieved when 260 ml of anidulafungin solution, which has a concentration of 0.77 mg/ml, are delivered in 3 hours. What is the maximum infusion rate in milligrams per minute? A loading dose of voriconazole consists of 5 mg for every kilogram of body mass. This dose is administered as two IV infusions separated by 12 hours. The concentration of the solution is 10 mg/ml. If a...
A drug (CL = 6 L/h, Va= 150 L) is to be administered as an IV...
A drug (CL = 6 L/h, Va= 150 L) is to be administered as an IV infusion. A steady-state plasma concentration of 1.2 mg L is desired. Calculate the following: (a) a suitable infusion rate, Rint (b) assuming it would take 4 half-lives to achieve the steady-state, how long would it take this drug to achieve this steady-state, tss (c) the value of a loading dose that would immediately achieve the desired steady-state plasma concentration of 1.2 mg/L, DL (d)...
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized...
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized and administered DRUG-A (F 0.02; fe 0.03; t24 hours; Vd 1.2 L/kg) as an iv-infusion. The effective plasma concentration for Drug A is 3 ug/mL a. Calculate the infusion rate necessary to maintain a steady state plasma concentration of 3 ug/mL. b Calculate how long it will take to reach 90% of steady state c. Calculate the loading dose. 2. After three days of...
an iv infusion of ganciclovir is administered to a patient whose weight is 187 pounds. A...
an iv infusion of ganciclovir is administered to a patient whose weight is 187 pounds. A dose of ganciclovir is administered at a rate of 5 mg/hr for every kilogram of body mass. Two 1-hour infusions are given each day for a minimum of 14 days. If the concentration of ganciclovir is 50 mg/ml, how many milliliters are required for a two-week regimen of ganciclovir?
When 800 mg of a new drug under study is administered IV in normal volunteers, 800...
When 800 mg of a new drug under study is administered IV in normal volunteers, 800 mg are recovered unchanged in urine. The AUC obtained after IV injection is 400 mg.h/L and the half life is 8 hours. When 400 mg are orally administered in volunteers 350 mg of drug are recovered unchanged in urine. Calculate: K, Kr, Vd, and oral bioavailability (F). thats all the data i have
BJ is a 70 year old female who is administered a drug via continuous IV infusion....
BJ is a 70 year old female who is administered a drug via continuous IV infusion. The volume of distribution is 51 L and a half life of 19.8 hours. The drug concentration 19 hours after the infusion was started is reported to be 0.69 mg/L. What is the rate of infusion? Note: Assume the infusion is ongoing. Please provide your answer in units of mg/hr.
EW is a 68 year old male who is administered a drug via continuous IV infusion....
EW is a 68 year old male who is administered a drug via continuous IV infusion. The volume of distribution is 56 L and a half life of 16.7 hours. The drug concentration 36 hours after the infusion was started is reported to be 1.84 mg/L. What is the rate of infusion? Note: Assume the infusion is ongoing. Please provide your answer in units of mg/hr:
WK is a 60 year old female who is administered a drug via continuous IV infusion....
WK is a 60 year old female who is administered a drug via continuous IV infusion. The volume of distribution is 63 L and a half life of 16.8 hours. The drug concentration 29 hours after the infusion was started is reported to be 1.11 mg/L. What is the rate of infusion? Note: Assume the infusion is ongoing. Please provide your answer in units of mg/hr
A 199 lb patient is ordered to receive intermittent IV infusions of a drug. This drug...
A 199 lb patient is ordered to receive intermittent IV infusions of a drug. This drug has a population-based Vd of o. Lkg and a 6 hr elimination half-life. The ordering physician has indicated the rate of drug infusion should be 150 mg/hr for a total time of 2 hours. Assume the nurse will set the infusion pump to be 2 mL/min. You must now prepare the small volume parenteral bag containing the drug. What should be the drug concentration...
15. Ampicillin 500 mg IV q6h. How many cc of the drug will be administered if...
15. Ampicillin 500 mg IV q6h. How many cc of the drug will be administered if the stock is 1 g vial? IV. Dosage Calculation by Body Mass 16. Fluorouracil 12 mg/kg/day IV, not to exceed 800 mg/day. The adult weighs 132 lbs. How many mg of the drug should the client receive per day? 17. Luminal 10 mg/kg IV. Client weighs 45 kg. How many ml should be administered if the stock is 130 mg/ml? 18. Diphenhydramine 50 mg...
A drug (CL = 6 L/h, Va= 150 L) is to be administered as an IV infusion. A steady-state plasma concentration of 1.2 mg L is desired. Calculate the following: (a) a suitable infusion rate, Rint (b) assuming it would take 4 half-lives to achieve the steady-state, how long would it take this drug to achieve this steady-state, tss (c) the value of a loading dose that would immediately achieve the desired steady-state plasma concentration of 1.2 mg/L, DL (d)...
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized and administered DRUG-A (F 0.02; fe 0.03; t24 hours; Vd 1.2 L/kg) as an iv-infusion. The effective plasma concentration for Drug A is 3 ug/mL a. Calculate the infusion rate necessary to maintain a steady state plasma concentration of 3 ug/mL. b Calculate how long it will take to reach 90% of steady state c. Calculate the loading dose. 2. After three days of...
EW is a 68 year old male who is administered a drug via continuous IV infusion. The volume of distribution is 56 L and a half life of 16.7 hours. The drug concentration 36 hours after the infusion was started is reported to be 1.84 mg/L. What is the rate of infusion? Note: Assume the infusion is ongoing. Please provide your answer in units of mg/hr:
WK is a 60 year old female who is administered a drug via continuous IV infusion. The volume of distribution is 63 L and a half life of 16.8 hours. The drug concentration 29 hours after the infusion was started is reported to be 1.11 mg/L. What is the rate of infusion? Note: Assume the infusion is ongoing. Please provide your answer in units of mg/hr
A 199 lb patient is ordered to receive intermittent IV infusions of a drug. This drug has a population-based Vd of o. Lkg and a 6 hr elimination half-life. The ordering physician has indicated the rate of drug infusion should be 150 mg/hr for a total time of 2 hours. Assume the nurse will set the infusion pump to be 2 mL/min. You must now prepare the small volume parenteral bag containing the drug. What should be the drug concentration...
15. Ampicillin 500 mg IV q6h. How many cc of the drug will be administered if the stock is 1 g vial? IV. Dosage Calculation by Body Mass 16. Fluorouracil 12 mg/kg/day IV, not to exceed 800 mg/day. The adult weighs 132 lbs. How many mg of the drug should the client receive per day? 17. Luminal 10 mg/kg IV. Client weighs 45 kg. How many ml should be administered if the stock is 130 mg/ml? 18. Diphenhydramine 50 mg...
Most questions answered within 3 hours.
-
Blossom Company owns 10000 of the 50000 outstanding shares of
Taylor, Inc. common stock. During 2018,...
asked 1 hour ago -
Calculate the following: ***SHOW ALL WORK!!!! Or
NO CREDIT*** Circle your answers. 8pts
each
In the...
asked 3 hours ago -
Bank Z is currently advertising interest rates on its checking
account. They claim to pay an...
asked 2 hours ago -
List two ways of transformation on the response variable that
can be used to deal with...
asked 3 hours ago -
If a 2000 ohm resistor has a -3.90 mA current going through it.
What is the...
asked 3 hours ago -
Please comment on the sentences.
Some types of jobs require more training than others. Some
companies...
asked 4 hours ago -
The )G01 for the hydrolysis of phosphorarginine
reaction depicted below is –32 kJ mol-1.
Phosphoarginine ...
asked 5 hours ago -
Cross a heterozygous blue-eyed goat with a homozygous brown-eyed
goat. Be sure to indicate which kids...
asked 5 hours ago -
Use the following information to answer the next two
questions.
Please refer to question 9-90. A...
asked 5 hours ago -
A solution containing 0.050 g of an unknown electrolyte in 2.50
g of cyclohexane was found...
asked 5 hours ago -
Question 1
a) Hydraulic conductivity of soils is an important parameter for
the design of engineering...
asked 5 hours ago -
Suppose your credit card balance is
$15,000
The minimum payment is
$313
and the annual percentage...
asked 5 hours ago