Question

When 800 mg of a new drug under study is administered IV in normal volunteers, 800 mg are recovered unchanged in urine. The AUC obtained after IV injection is 400 mg.h/L and the half life is 8 hours. When 400 mg are orally administered in volunteers 350 mg of drug are recovered unchanged in urine. Calculate: K, K_r, Vd, and oral bioavailability (F).

thats all the data i have

Answer 1

Answer= Onit time oka fraction of drug that is removed per measured at any particular Instant K= 0.693 t² = 0.693 8 hrs K = 0.0866 . Va= Volume of Distribution it is the Volume that would be Necessary to contain the total amount of adninisted drug at the same concentration that is obrewed in blood plasma Whene Co- aneount of De Amount of Drug contained in body Drug Administed 1 va = goong goong

• Bio annilability is the fraction of administered doce of Unchanged drog that reaches Systemic Circulation So, Oral Rioavailability Administred by Orel Porto - 400 mg Drug Reached Systemic - 350 mag. Circulation - 350 mag Ond sisarailability - 350 x 100 % Bioavailability 87.5% Yoe
k value comes out to be 0.086 /hr

Volume of distribution comes out to be 1

Oral Bioavailability is 87.5%