The antifungal drug anidulafungin is administered by IV
infusion. The maximum infusion rate is achieved when 260 ml of
anidulafungin solution, which has a concentration of 0.77 mg/ml,
are delivered in 3 hours. What is the maximum infusion rate in
milligrams per minute?
A loading dose of voriconazole consists of 5 mg for every kilogram of body mass. This dose is administered as two IV infusions separated by 12 hours. The concentration of the solution is 10 mg/ml. If a patient weighs 132 pounds, how many milliliters of voriconazole are administered in a day?
Valacyclovir is an antiviral drug that interferes with the replication process of a virus. For the treatment of Herpes zoster, the typical dose consists of 1000 mg administered three times a day over a period of 7 days. How many 1000 mg tablets of valacyclovir are needed?
An IV infusion of ganciclovir is administered to a patient whose weight is 187 pounds. A dose of ganciclovir is administered at a rate of 5 mg/hr for every kilogram of body mass. Two 1-hour infusions are given each day for a minimum of 14 days. If the concentration of ganciclovir is 50 mg/ml, how many milliliters are required for a two-week regimen of ganciclovir?
1. The maximum infusion rate is achieved when 260 ml of anidulafungin solution, which has a concentration of 0.77 mg/ml, are delivered in 3 hours.
Means 0.77mg in 1 ml
Or 1 ml contains 0.77 mg
Then 260 ml will contain=0.77X260=200.2 mg
Then infusion rate in milligrams per minute= 200/ (3X60) = 1.11mg/min
2.Loading dose = 5 mg/kg
Patient weighs 132 pounds=60 kg.
Total dose as per weight will be required=60X 5=300mg
Available concent. = 10 mg/ml.
Required dose in ml=?
10mg in 1 ml
1mg in=1/10 ml
300mg will be available in/ supplied by the=(1/10)X300=30 ml
3.For the treatment of Herpes zoster, the typical dose consists of 1000 mg administered three times a day over a period of 7 days.
Per day amount =3000mg
For 7 days=7x3000=21000mg
How many 1000 mg tablets of valacyclovir are needed?
1000mg by 1 tablet then 21000mg from 21 tablets will be
required
4. A dose of ganciclovir is administered at a rate of 5 mg/hr for every kilogram of body mass. Patient weight= 187 pounds= 85kg
Total required dose as the weight is concerened=85X5=425mg/hr
Available concentration of ganciclovir is= 50 mg/ml
425mg=425/50ml=8.5 ml
Required infusion in ml/hr=8.5ml/hr
Two 1-hour infusions are given each day for a minimum of 14 days.
Then per day required ml=8.5X 2=17ml/day
How many milliliters are required for a two-week regimen of ganciclovir?
17ml/day
Then for two week regimen requiredml=17X14=238ml
The antifungal drug anidulafungin is administered by IV infusion. The maximum infusion rate is achieved when...
an iv infusion of ganciclovir is administered to a patient whose weight is 187 pounds. A dose of ganciclovir is administered at a rate of 5 mg/hr for every kilogram of body mass. Two 1-hour infusions are given each day for a minimum of 14 days. If the concentration of ganciclovir is 50 mg/ml, how many milliliters are required for a two-week regimen of ganciclovir?
A loading dose of voriconazole consists of 5 mg for every kilogram of body mass. This dose is administered as two IV infusions separated by 12 hours. The concentration of the solution is 10 mg/ml. If a patient weighs 132 pounds, how many milliliters of voriconazole are administered in a day?
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Metronidazole is used in the treatment of anaerobic protozoal infections. Although often administered orally, it can also be delivered by means of an IV infusion. The loading dose is 15 mg per kilogram of body mass and is infused over one hour. The maintenance dose is 7.5 mg per kilogram of body mass, is also infused over an hour, and is administered six hours after the loading dose. If the concentration of the metronidazole solution is 5 mg/ml, how many...
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