the two carboxylic acid groups of aspartic acid have different acidities with pKa values of 2.1 and 3.9. Predict which acid group is the more acidic by considering the effect of the -nh3+ group on the stability of the conjugate bases. Explain your reasoning.
the two carboxylic acid groups of aspartic acid have different acidities with pKa values of 2.1...
What is the pI value for aspartic acid, which has pKa values of 2.1, 3.9, and 9.8? The answer is (2.1+3.9)/2 = 3.0 What happen to 9.8?? Why this number is not included?
The carboxylic acid group (COOH) in the side chain of Aspartic acid (shown below), one of the 20 naturally occurring amino acids, has a pKa of 4.1. Calculate the percentage of conjugate base (COO- ) for this carboxylic acid group in the side chain of Aspartate at the following pH values: 2.1 , 4.1 and 5.1.
OH pka 3.1 pKa 4.5 HO -OH pka 5.8 depicts the structure of citric acid with the corresponding pka values for each of the three acids. a. Explain why the carboxylic acid at the top of the structure is the most acidic. b. Suggest a reason why the remaining two acids would have different pka values.
Maleic acid contains two carboxylic acid groups, one with a pka of 2.0 and a second with a pKa of 4.0. The fully protonated from of malice acid is shown on below. Briefly describe how you would prepare 0.25L of a 0.1 M buffer at pH = 2.0, assuming that you are starting with the disodium salt of the acid. You should give the moles of sodium malate (MW 178.05 g/mol ) and HCL (36.46 g/mol) that you would need...
Explain why amino acid functional groups that participate in acid-base chemistry have perturbed pKa values from simple methyl substituted amino and carboxyl groups. (3 points) Explain why amino acid functional groups that participate in acid-base chemistry have perturbed pKa values from simple methyl substituted amino and carboxyl groups. (3 points)
What is the correct structure of cysteine at pH 137 The pKa values are 1.7 (carboxylic acid), 10.8 (amine (conjugate acid)), and 8.3 (sidechain, thiol). ΝΗ, * _dp OH ΝΗ, HS H2 -CÁCH NH2 CH es O Arrange the indicated protons by acidity, most acidic first: So ho į III IV OI>I> III > IV 01>II> III > IV 01> IV> III > II >I> IV > III Friedel-Crafts alkylation reactions cannot be performed on aniline because: The amino group...
What about the pKa values of the R groups of the seven amino acids containing an ionizable R group? Tyr 10.5 Lys 10.5 Arg 12.5 Asp 3.9 Glu 4.1 His 6.0 Cys 8.4 Indicate the approximate net charge of each of these seven R groups at pH 7.4. Indicate the approximate net charge of each of these seven amino acids at pH 7.4. Note: remember the carboxyl and the alpha-amino group in addition to the ionizable (acidic or basic) R...
Explain why the different positions have different pKa values, using resonance structures. The pka of phenol (C6H5OH) is 10.0. When a nitro group (NO) is attached to the ring, the pka decreases. Explain why the different positions have different pka values, using resonance structures. OH OH OH - ၄ NO, NO₂ 10. 0 pK, = 7 .23 8.35 7.1
Organic Chemistry 4. Below are two molecules, B and C. Explain the differences in pKa of the two molecules by drawing the conjugate base of molecule C and a resonance structure that would not be found in molecule B. Hint: Draw out the NO2 group. conjugate base of molecule C pKa- 29.5 molecule B NO2 pka= 8.6 molecule C 5. Below is the molecule Abilify, which is a top selling drug that is used to treat schizophrenia, bipolar disorder and...
Can someone help with the 4 POST LAB questions thanks Carboxylic Acids and Esters acid). like citric acid. Face crearboxyl the name implies, a Carbexylic Aclds A salad dressing made of The sour taste of fruits such as lemons is due to the presence of acids like citric acid. tcarboxyl a-hydroxy acids such functional group - that is, a carbonyl group attached to a hydroxyl group. AS dicarboxylic acid carboxylic acid of benzene is called benzoic acid (Figure 1). oil...