Question

Organic Chemistry

4. Below are two molecules, B and C. Explain the differences in pKa of the two molecules by drawing the conjugate base of molecule C and a resonance structure that would not be found in molecule B. Hint: Draw out the NO2 group. conjugate base of molecule C pKa- 29.5 molecule B NO2 pka= 8.6 molecule C 5. Below is the molecule Abilify, which is a top selling drug that is used to treat schizophrenia, bipolar disorder and depression. Answer the following questions about Abilifjy a) Circle the most basic atom in Abilify. b) The pKa of the conjugate acid of the most basic atom of Abilify is around 10. Circle the acids below that can completely protonate the most basic atom in Abilify (Keqp 103 H-CI OH Abilify H 6. Put the compounds below in order of most acidic to least acidic NH2 NH2 NH2H3C most acidic least acidic 7. For the following pairs of molecules, circle the molecule that is the most basic of the pair OCH3 c) CEN

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