Explain why amino acid functional groups that participate in acid-base chemistry have perturbed pKa values from sim...
Why do the pKa values of ionizable groups differ between free amino acids and amino acid residues in polypeptides? thanks
Please Explain: 7) a. Why does an acid and its conjugate base have the same pKa and Ka values? b. Why does a base and its conjugate acid have the same pKa and Ka values? Thank You! <3
2) A) Amino acids such as Phe and Val are not known to participate directly in acid-base or covalent catalysis. Explain why B) Mutating a Phe and Val can still have dramatic effects on enzyme activity. Why? 2) A) Amino acids such as Phe and Val are not known to participate directly in acid-base or covalent catalysis. Explain why B) Mutating a Phe and Val can still have dramatic effects on enzyme activity. Why?
What about the pKa values of the R groups of the seven amino acids containing an ionizable R group? Tyr 10.5 Lys 10.5 Arg 12.5 Asp 3.9 Glu 4.1 His 6.0 Cys 8.4 Indicate the approximate net charge of each of these seven R groups at pH 7.4. Indicate the approximate net charge of each of these seven amino acids at pH 7.4. Note: remember the carboxyl and the alpha-amino group in addition to the ionizable (acidic or basic) R...
please explain 55. At its isolectric pH, glycine will have both of its ionizable functional groups dissociated. neither of its ionizable functional groups dissociated only its carboxyl group dissociated. only its amino group dissociated. a. b. c. d.
Provide approximate pKa values for the following functional groups or compounds and provide and example of each: 1) alkane 2) alkene 3) alkyne 4) alcohol 5) phenol 6) water 7) ketone/aldehyde 8) carboxylic acid 9) amine
the two carboxylic acid groups of aspartic acid have different acidities with pKa values of 2.1 and 3.9. Predict which acid group is the more acidic by considering the effect of the -nh3+ group on the stability of the conjugate bases. Explain your reasoning.
(References Explain why an amino acid will not exist in an un-ionized form at any pH. All amino acids have a carboxyl group that is a stronger acid than water and an amino group that is a stronger acid than water. When lots of hydrogen ions are present (meaning the pH is relatively low), the carboxyl group is protonated and the amino group is unaffected When lots of hydroxide ions are present (meaning the pH is relatively high), the carboxyl...
2. A structure of Luminol is shown with all functional groups protonated and their pka labeled. Use words and structures to answer a and b. Luminol pke 2 9 a. Acetic acid was added at the end of the reduction step to obtain a pH of - 3-4.2pts i. Draw the structure of the luminol at pH 3. ii. Refering to the structure in a.i.), explain why the luminol precipitates from the aqueous solution at this pH. NH₂ NH N-H...
Explain why the different positions have different pKa values, using resonance structures. The pka of phenol (C6H5OH) is 10.0. When a nitro group (NO) is attached to the ring, the pka decreases. Explain why the different positions have different pka values, using resonance structures. OH OH OH - ၄ NO, NO₂ 10. 0 pK, = 7 .23 8.35 7.1