Why do the pKa values of ionizable groups differ between free amino acids and amino acid...
Why do the pKa values of ionizable groups differ between free amino acids and amino acid residues in polypeptides? thanks
Homework Answers
Solution:
The pKa values of ionizable groups differ between free amino acids and amino acid residues in polypeptides are due to electrostatic interactions of ionizable side chain groups of polypeptides with other charged and polar side chains present in polypeptide.
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Why do the pKa values of ionizable groups differ
between free amino acids and amino acid...
What about the pKa values of the R groups of the seven amino acids containing an...
What about the pKa values of the R groups of the seven amino acids containing an ionizable R group? Tyr 10.5 Lys 10.5 Arg 12.5 Asp 3.9 Glu 4.1 His 6.0 Cys 8.4 Indicate the approximate net charge of each of these seven R groups at pH 7.4. Indicate the approximate net charge of each of these seven amino acids at pH 7.4. Note: remember the carboxyl and the alpha-amino group in addition to the ionizable (acidic or basic) R...
A student performed a titration of an unknown amino acid that had two ionizable groups. The...
A student performed a titration of an unknown amino acid that had two ionizable groups. The student determined the pKa values to be 4.79 and 10.20. What is the isoelectric point? (2 points)
Explain why amino acid functional groups that participate in acid-base chemistry have perturbed pKa values from sim...
Explain why amino acid functional groups that participate in acid-base chemistry have perturbed pKa values from simple methyl substituted amino and carboxyl groups. (3 points)
Explain why amino acid functional groups that participate in acid-base chemistry have perturbed pKa values from simple methyl substituted amino and carboxyl groups. (3 points)
What is isoelectric point? The amino acid glycine has two ionizable groups: 1) a carboxyl acid...
What is isoelectric point? The amino acid glycine has two ionizable groups: 1) a carboxyl acid group with a pKa of 2.72 and 2) an amino group with a pKa of 9.60. Calculate the pI of glycine.
Look up the exact pKa's of the two ionizable groups for the amino acid methionine. a)...
Look up the exact pKa's of the two ionizable groups for the amino acid methionine. a) fill out a table that gives the charge on each ionizable group and the overall charge on the amino acid for eacu whole pH unit from 0 to 12 b) calculate the isoelectric point of met exactly c) compare your calculated pI from (c) with your table. d) draw the structure of the amino acid at pH 0, 7.4, and 12.
Lecture 3 Identify amino-/carboxy termini, and R-group on amino acid What is chirality? Identify a carbon...
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There are four amino acid residues between each turn of an alpha helix, because O hydrogen...
There are four amino acid residues between each turn of an alpha helix, because O hydrogen bonding between the carbonyl and amine groups is more stable at this distance. O amino acid residues need a certain amount of distance between then during the turn. O the polar amino acids are more attractive to the peptide bond at this distance. O None of the choices are correct.
For the following amino acids - explain why the overall charge on the amino acid is...
For the following amino acids - explain why the overall charge on the amino acid is different at PH's 2, 7, and 11. Relate it to the pk, of the groups on the molecules To achieve distinction, you must explain that the form of an amino acid, whether positively charged, negatively charged or neutral, depends on the pH of the solution and also on the Ka of the acid group
Number of amino acids in between each turn of an a-helix? The backbone polypeptides in a...
Number of amino acids in between each turn of an a-helix? The backbone polypeptides in a parallel b-sheet run the and the backbone polypeptides in an antiparallel b-sheet run the direction direction In both an a-helix and b-sheet, the interactions are accomplished by these two functional groups on the amino acids: Q7: Protein Kinase/Protein Phosphatase Both kinases and Phosphatases involve the transfer of this: Most kinases use this molecule (listed in part a) as a donor.
The bond that forms between amino acids: a) connects water molecules and carboxyl groups of adjacent...
The bond that forms between amino acids: a) connects water molecules and carboxyl groups of adjacent amino acids. b) connects amino groups and carboxyl groups of adjacent amino acids c) connects amino groups and R groups of adjacent amino acids d)can form between any chemical groups of adjacent amino acids e) connects hydrogen atoms of adjacent amino acids.
A student performed a titration of an unknown amino acid that had two ionizable groups. The student determined the pKa values to be 4.79 and 10.20. What is the isoelectric point? (2 points)
Explain why amino acid functional groups that participate in acid-base chemistry have perturbed pKa values from simple methyl substituted amino and carboxyl groups. (3 points)
Explain why amino acid functional groups that participate in acid-base chemistry have perturbed pKa values from simple methyl substituted amino and carboxyl groups. (3 points)
Lecture 3 Identify amino-/carboxy termini, and R-group on amino acid What is chirality? Identify a carbon that is chiral (i.e., has 4 different groups attached) Chiral compounds rotate plane polarized light Memorize amino acid 1) structure, 2) classification (hydrophobic, aliphatic, aromatic, negatively charged, positively charged, polar uncharged) Be able to draw glycine (the generic amino acid) Given an amino acid structure and pKas of ionizable groups, be able to determine the charge at pH 1, pH 14, and pH 7...
There are four amino acid residues between each turn of an alpha helix, because O hydrogen bonding between the carbonyl and amine groups is more stable at this distance. O amino acid residues need a certain amount of distance between then during the turn. O the polar amino acids are more attractive to the peptide bond at this distance. O None of the choices are correct.
For the following amino acids - explain why the overall charge on the amino acid is different at PH's 2, 7, and 11. Relate it to the pk, of the groups on the molecules To achieve distinction, you must explain that the form of an amino acid, whether positively charged, negatively charged or neutral, depends on the pH of the solution and also on the Ka of the acid group
Number of amino acids in between each turn of an a-helix? The backbone polypeptides in a parallel b-sheet run the and the backbone polypeptides in an antiparallel b-sheet run the direction direction In both an a-helix and b-sheet, the interactions are accomplished by these two functional groups on the amino acids: Q7: Protein Kinase/Protein Phosphatase Both kinases and Phosphatases involve the transfer of this: Most kinases use this molecule (listed in part a) as a donor.
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