Homework Answers
Part a.
The carboxylic acid at the top of the structure is attached to the carbon where the electronegative oxygen atom is directly attached, due to which the corresponding proton can be readily donated, i.e. most acidic.
Part b.
One of the carboxylic acids is near to the OH group attached to central carbon-atom, hence they each can form hydrogen bonding, as a result, the corresponding proton is comparatively acidic (less pKa, i.e. 4.5) than the one which is oriented far (more pKa, i.e. 5.8) from it.
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OH pka 3.1 pKa 4.5 HO -OH pka 5.8 depicts the structure of citric acid with the corresponding pka values for each o...
Phosphoric acid (structure shown below) is a common acid used in buffer solutions. Even though the...
Phosphoric acid (structure shown below) is a common acid used in
buffer solutions. Even though the structure shows three equivalent
hydrogen atoms, there are three different pKa values associated
with the compound (pKa1 ≈ 2, pKa2 ≈ 7, pKa3 ≈ 12). Why do the three
hydrogen atoms have different pKa values? How many of the hydrogen
atoms will be removed in a buffer solution at pH 4?
OH HO-P-OH
What is the correct structure of cysteine at pH 137 The pKa values are 1.7 (carboxylic...
What is the correct structure of cysteine at pH 137 The pKa values are 1.7 (carboxylic acid), 10.8 (amine (conjugate acid)), and 8.3 (sidechain, thiol). ΝΗ, * _dp OH ΝΗ, HS H2 -CÁCH NH2 CH es O Arrange the indicated protons by acidity, most acidic first: So ho į III IV OI>I> III > IV 01>II> III > IV 01> IV> III > II >I> IV > III Friedel-Crafts alkylation reactions cannot be performed on aniline because: The amino group...
Acid pka Conjugated base Acid OH 00 15.2 H SO HyC HO- 15.7 17 HO+ NH...
Acid pka Conjugated base Acid OH 00 15.2 H SO HyC HO- 15.7 17 HO+ NH "NH wo HAC CHE HOC HọcoỒ CH, Họco CHỊ | пен HC- H H ,C- 25.5 NHA 0910 . NH NH₂. 38 NO2 10.5 | 20 11 21 un 5 HC-SH CH₃- 48 OCH, Assignment: First, find your name in the next pages. Beside your name, 3 acid-base couples are given by numbers. They refer to acid or base find in the table on...
(b) The amino acid lysine has the following values of pK : PK1 =2.2, pK2 = 8.9, PKR = 10.5 (the pK, of the amino gro...
(b) The amino acid lysine has the following values of pK : PK1 =2.2, pK2 = 8.9, PKR = 10.5 (the pK, of the amino group in the side chain). At pH 7 it has the structure shown below (6). Draw the structure that you would expect for lysine at pH 9.7, indicating the charges as appropriate. HZN 0 HINA (2 marks) (c) Phenol (C6H5OH) and 2,4,6-trichlorophenol (C6H2C13OH) are both weak acids with pK, values of 9.89 and 6.21, respectively,...
please answer part (ii) (b) The amino acid lysine has the following values of pK :...
please answer part (ii)
(b) The amino acid lysine has the following values of pK : PK1 =2.2, pK2 = 8.9, PKR = 10.5 (the pK, of the amino group in the side chain). At pH 7 it has the structure shown below (6). Draw the structure that you would expect for lysine at pH 9.7, indicating the charges as appropriate. HZN 0 HINA (2 marks) (c) Phenol (C6H5OH) and 2,4,6-trichlorophenol (C6H2C13OH) are both weak acids with pK, values of...
Organic Chemistry 4. Below are two molecules, B and C. Explain the differences in pKa of...
Organic Chemistry
4. Below are two molecules, B and C. Explain the differences in pKa of the two molecules by drawing the conjugate base of molecule C and a resonance structure that would not be found in molecule B. Hint: Draw out the NO2 group. conjugate base of molecule C pKa- 29.5 molecule B NO2 pka= 8.6 molecule C 5. Below is the molecule Abilify, which is a top selling drug that is used to treat schizophrenia, bipolar disorder and...
HO CH сн. CH2 нс HC CH3 HAC-HC CH CH CH CH d) OH OH 13....
HO CH сн. CH2 нс HC CH3 HAC-HC CH CH CH CH d) OH OH 13. The labels have fallen off three bottles. Bottle A contains a gas, bottle B contains a liquid, and bottle C contains a solid. The labels indicate that the compounds have the same number of carbon atoms, one being an alkane, one an alcohol, and the other a carboxylic acid. Suggest the identity of the contents of each bottle, and give reasons for your explanation...
1. (6 pts total; 2 pts each) Proteins that catalyze chemical reactions in living systems are...
1. (6 pts total; 2 pts each) Proteins that catalyze chemical reactions in living systems are called enzymes. The basic building blocks of proteins are called amino acids and have the general structure pictured below, left, where R is a substituent containing one of many organic functional groups. Some representative examples of amino acids found in nature are pictured here as well (R groups only) сн. н 0:00 HO-C-H. HỌC-C-CH, CH,SH H-C-H H2N -CO,H H An Amino Acid Threonine Valine...
Discussion Questions The structures of acetanilide and malonic acid are provided below 1. For each structure,...
Discussion Questions The structures of acetanilide and malonic acid are provided below 1. For each structure, draw circles around the polar and nonpolar regions of the molecule, and label each circled regiorn with the type of intermolecular attractive force it can use to interact with other molecules. Acetanilide Malonic Acid но CH2 OH 2. Now-thoroughly explain (on the basis of polarity/nonpolarity and intermolecular attractive forces) how the acetanilide was separated from the malonic acid by recrystallization from water. And explain...
Exercise 2 Separation of a Mixture Based on Acid-Base Properties One purpose of this exercise is...
Exercise 2 Separation of a Mixture Based on Acid-Base Properties One purpose of this exercise is to learn how to use a separatory funnel to extract a single component away from other compounds in solution. To do so, we will apply the principles of solubility and acid-base behavior you’re seeing in class. One of the compounds is neutral in the acid-base sense. It has no ability to either donate or accept a proton from an aqueous solution, and will remain...
Phosphoric acid (structure shown below) is a common acid used in
buffer solutions. Even though the structure shows three equivalent
hydrogen atoms, there are three different pKa values associated
with the compound (pKa1 ≈ 2, pKa2 ≈ 7, pKa3 ≈ 12). Why do the three
hydrogen atoms have different pKa values? How many of the hydrogen
atoms will be removed in a buffer solution at pH 4?
OH HO-P-OH
What is the correct structure of cysteine at pH 137 The pKa values are 1.7 (carboxylic acid), 10.8 (amine (conjugate acid)), and 8.3 (sidechain, thiol). ΝΗ, * _dp OH ΝΗ, HS H2 -CÁCH NH2 CH es O Arrange the indicated protons by acidity, most acidic first: So ho į III IV OI>I> III > IV 01>II> III > IV 01> IV> III > II >I> IV > III Friedel-Crafts alkylation reactions cannot be performed on aniline because: The amino group...
Acid pka Conjugated base Acid OH 00 15.2 H SO HyC HO- 15.7 17 HO+ NH "NH wo HAC CHE HOC HọcoỒ CH, Họco CHỊ | пен HC- H H ,C- 25.5 NHA 0910 . NH NH₂. 38 NO2 10.5 | 20 11 21 un 5 HC-SH CH₃- 48 OCH, Assignment: First, find your name in the next pages. Beside your name, 3 acid-base couples are given by numbers. They refer to acid or base find in the table on...
(b) The amino acid lysine has the following values of pK : PK1 =2.2, pK2 = 8.9, PKR = 10.5 (the pK, of the amino group in the side chain). At pH 7 it has the structure shown below (6). Draw the structure that you would expect for lysine at pH 9.7, indicating the charges as appropriate. HZN 0 HINA (2 marks) (c) Phenol (C6H5OH) and 2,4,6-trichlorophenol (C6H2C13OH) are both weak acids with pK, values of 9.89 and 6.21, respectively,...
please answer part (ii)
(b) The amino acid lysine has the following values of pK : PK1 =2.2, pK2 = 8.9, PKR = 10.5 (the pK, of the amino group in the side chain). At pH 7 it has the structure shown below (6). Draw the structure that you would expect for lysine at pH 9.7, indicating the charges as appropriate. HZN 0 HINA (2 marks) (c) Phenol (C6H5OH) and 2,4,6-trichlorophenol (C6H2C13OH) are both weak acids with pK, values of...
Organic Chemistry
4. Below are two molecules, B and C. Explain the differences in pKa of the two molecules by drawing the conjugate base of molecule C and a resonance structure that would not be found in molecule B. Hint: Draw out the NO2 group. conjugate base of molecule C pKa- 29.5 molecule B NO2 pka= 8.6 molecule C 5. Below is the molecule Abilify, which is a top selling drug that is used to treat schizophrenia, bipolar disorder and...
HO CH сн. CH2 нс HC CH3 HAC-HC CH CH CH CH d) OH OH 13. The labels have fallen off three bottles. Bottle A contains a gas, bottle B contains a liquid, and bottle C contains a solid. The labels indicate that the compounds have the same number of carbon atoms, one being an alkane, one an alcohol, and the other a carboxylic acid. Suggest the identity of the contents of each bottle, and give reasons for your explanation...
1. (6 pts total; 2 pts each) Proteins that catalyze chemical reactions in living systems are called enzymes. The basic building blocks of proteins are called amino acids and have the general structure pictured below, left, where R is a substituent containing one of many organic functional groups. Some representative examples of amino acids found in nature are pictured here as well (R groups only) сн. н 0:00 HO-C-H. HỌC-C-CH, CH,SH H-C-H H2N -CO,H H An Amino Acid Threonine Valine...
Discussion Questions The structures of acetanilide and malonic acid are provided below 1. For each structure, draw circles around the polar and nonpolar regions of the molecule, and label each circled regiorn with the type of intermolecular attractive force it can use to interact with other molecules. Acetanilide Malonic Acid но CH2 OH 2. Now-thoroughly explain (on the basis of polarity/nonpolarity and intermolecular attractive forces) how the acetanilide was separated from the malonic acid by recrystallization from water. And explain...
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