A 500 mg iv-bolus of drug A is administered to a subject at 8 am. The drug has a CL of 4 L/hr. What is the percentage eliminated in the first 6 hours, given an AUC0-6 hours of 25 mg/L/hr? |
A 500 mg iv-bolus of drug A is administered to a subject at 8 am. The...
When a 120 mg IV-Bolus of Drug A is administered to a patient, an AUC -60 mg/L/hr is observed. Knowing that Drug A has an half-life of 12 hours, calculate the volume of distribution of Drug A in liters
do asap You have administered 50 mg of theophylline by IV bolus which has an elimination rate constant of 0.289/hr. What fraction remains after 12 hours? Express your answer with 5 decimal places
A 90 kg man was administered a 0.044 mg/kg dose of lorazepam by iv bolus for pre-operative sedation. A plasma concentration of 0.066 mg/L resulted after the administration was complete and was 0.0165 mg/L 20 hours later. What is the VD .ke dose . 1112 the number of half-lives that have elapsed and clearance
15. Ampicillin 500 mg IV q6h. How many cc of the drug will be administered if the stock is 1 g vial? IV. Dosage Calculation by Body Mass 16. Fluorouracil 12 mg/kg/day IV, not to exceed 800 mg/day. The adult weighs 132 lbs. How many mg of the drug should the client receive per day? 17. Luminal 10 mg/kg IV. Client weighs 45 kg. How many ml should be administered if the stock is 130 mg/ml? 18. Diphenhydramine 50 mg...
1. A new drug was given in a single intravenous dose of 200 mg to an 80- kg adult male patient. The apparent VD is 0.8 L/kg, and the drug is eliminated by 1st order kinetics. Compute the initial drug plasma concentration. 2. A drug has an elimination half-life of 4 hours and follows first-order kinetics. If a single 600-mg dose is given to a patient by IV bolus, what percent of the dose is lost in 12 hours?
QUESTION 4 Predict the plasma concentration (in mg/L) of Drug-A six (6) hours following the administrtion of a 50 mg IV Bolus to a 42 year old subject. Drug A has a half-life of 6 hours and a volume of distribution of 25 liters
14. Gentamicin is often given in IV-bolus doses of 100 mg every 8 hours to achieve an average steady-state plasmatic concentration of 5 mg/L. The total clearance is normally 5.4 L/h in a 70 Kg-body weight person. Gentamicin is entirely eliminated by glomerular filtration. Your patient, however, is found to have a creatinine clearance one-third of normal. Your initial dosage regimen for this patient would probably be: a. 20 mg every 8 hours b. 33 mg every 8 hours c....
When 800 mg of a new drug under study is administered IV in normal volunteers, 800 mg are recovered unchanged in urine. The AUC obtained after IV injection is 400 mg.h/L and the half life is 8 hours. When 400 mg are orally administered in volunteers 350 mg of drug are recovered unchanged in urine. Calculate: K, Kr, Vd, and oral bioavailability (F). thats all the data i have
BJ is a 70 year old female who is administered a drug via continuous IV infusion. The volume of distribution is 51 L and a half life of 19.8 hours. The drug concentration 19 hours after the infusion was started is reported to be 0.69 mg/L. What is the rate of infusion? Note: Assume the infusion is ongoing. Please provide your answer in units of mg/hr.
EW is a 68 year old male who is administered a drug via continuous IV infusion. The volume of distribution is 56 L and a half life of 16.7 hours. The drug concentration 36 hours after the infusion was started is reported to be 1.84 mg/L. What is the rate of infusion? Note: Assume the infusion is ongoing. Please provide your answer in units of mg/hr: