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Case 1 ( homework) A drug (200 mg) is administered to a 70-kg male patient...
Case 1 ( homework) A drug (200 mg) is administered to a 70-kg male patient by...
Case 1 ( homework) A drug (200 mg) is administered to a 70-kg male patient by multiple IV injections at 6-h intervals. The drug is water-soluble and has a distribution volume equivalent to that of total body water (50 liters). The drug has a biological half-life of 6 h. Calculate (Css (max), Css (min) and Cav(ss). The time necessary to reach 95% of the steady-state concentration. The number of doses required to reach 95% of the steady-state concentration.
A patient is administered a drug through IV infusion at a rate of 300 mg/h. The...
A patient is administered a drug through IV infusion at a rate of 300 mg/h. The drug is eliminated from the body via urine and the halflife is reported as 5h. Based on the patient’s weight, you are expecting a steady-state level of 7 mg/ml. A) Based on these assumptions, how much is Vd? B) A blood test shows that the concentration of the drug in the plasma is 15 mg/ml. Looking at your assumptions, what might have been wrong?...
drug a (t1/2= 18 hours, v= 80l fe= 0.2 fu= 0.1) is administered as multiple 200...
drug a (t1/2= 18 hours, v= 80l fe= 0.2 fu= 0.1) is administered as multiple 200 mg iv bolus every 12 hours. predict max concentration at steady state.
A drug (CL = 6 L/h, Va= 150 L) is to be administered as an IV...
A drug (CL = 6 L/h, Va= 150 L) is to be administered as an IV infusion. A steady-state plasma concentration of 1.2 mg L is desired. Calculate the following: (a) a suitable infusion rate, Rint (b) assuming it would take 4 half-lives to achieve the steady-state, how long would it take this drug to achieve this steady-state, tss (c) the value of a loading dose that would immediately achieve the desired steady-state plasma concentration of 1.2 mg/L, DL (d)...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized...
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized and administered DRUG-A (F 0.02; fe 0.03; t24 hours; Vd 1.2 L/kg) as an iv-infusion. The effective plasma concentration for Drug A is 3 ug/mL a. Calculate the infusion rate necessary to maintain a steady state plasma concentration of 3 ug/mL. b Calculate how long it will take to reach 90% of steady state c. Calculate the loading dose. 2. After three days of...
2. Steady State concentration 3 hours after last dose A patient receives a 1000 mg dose...
2. Steady State concentration 3 hours after last dose A patient receives a 1000 mg dose of an antibiotic every 6 hours by repetitive IV injection (ouch!). The drug has a Vo of 20 L and an elimination half-life of 3 hours. Ct (post ss) = xon-e-ke x e-kt
Azithromycin is sometimes prescribed for community acquired pneumonia as 500 mg PO on day 1 then...
Azithromycin is sometimes prescribed for community acquired pneumonia as 500 mg PO on day 1 then 250 mg PO on days 2-5. You are asked to evaluate the possible maximal lung concentration of azithromycin after the final dose according to these dosing instructions in a male patient who weighs 158 lb. A report in the literature stated that azithromycin lung concentrations are 1030% of azithromycin blood concentrations. Assume azithromycin has an elimination half-life of 53 hr, an absorption half-life of...
#1) While reviewing medication orders in a hospital, you encounter an order for tobramycin, an antibiotic,...
#1) While reviewing medication orders in a hospital, you encounter an order for tobramycin, an antibiotic, to be administered as intermittent intravenous infusions. Checking this order, you identify the following information: - The patient weighs 266 lbs - The physician ordered 5.2 mg/kg/day given in 6 divided doses - Each dose should be administered as an intermittent intravenous infusion - Each infusion should last 30 minutes - The technician has prepared a 150 mL small volume parenteral bag containing 9...
1. An IV bag contains 600mg of a drug in 200mL of NS the flow rate...
1. An IV bag contains 600mg of a drug in 200mL of NS the flow rate in ml/h and the dosage rate in mg/min. 10 B of a drug in 200mL of NS, and must infuse over 2 hours. Find 2. An IVPB bag containing 50 mg of drug in 100mL of solution must intus 2mg/min. If the infusion begins at 0800 h, when will it finish? of solution must infuse at the rate of 3. ANIVPB IS infusing at...
Case 1 ( homework) A drug (200 mg) is administered to a 70-kg male patient by multiple IV injections at 6-h intervals. The drug is water-soluble and has a distribution volume equivalent to that of total body water (50 liters). The drug has a biological half-life of 6 h. Calculate (Css (max), Css (min) and Cav(ss). The time necessary to reach 95% of the steady-state concentration. The number of doses required to reach 95% of the steady-state concentration.
A drug (CL = 6 L/h, Va= 150 L) is to be administered as an IV infusion. A steady-state plasma concentration of 1.2 mg L is desired. Calculate the following: (a) a suitable infusion rate, Rint (b) assuming it would take 4 half-lives to achieve the steady-state, how long would it take this drug to achieve this steady-state, tss (c) the value of a loading dose that would immediately achieve the desired steady-state plasma concentration of 1.2 mg/L, DL (d)...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
1. RM (65 kg) is a 78 years old-man with a heart condition. He is hospitalized and administered DRUG-A (F 0.02; fe 0.03; t24 hours; Vd 1.2 L/kg) as an iv-infusion. The effective plasma concentration for Drug A is 3 ug/mL a. Calculate the infusion rate necessary to maintain a steady state plasma concentration of 3 ug/mL. b Calculate how long it will take to reach 90% of steady state c. Calculate the loading dose. 2. After three days of...
2. Steady State concentration 3 hours after last dose A patient receives a 1000 mg dose of an antibiotic every 6 hours by repetitive IV injection (ouch!). The drug has a Vo of 20 L and an elimination half-life of 3 hours. Ct (post ss) = xon-e-ke x e-kt
Azithromycin is sometimes prescribed for community acquired pneumonia as 500 mg PO on day 1 then 250 mg PO on days 2-5. You are asked to evaluate the possible maximal lung concentration of azithromycin after the final dose according to these dosing instructions in a male patient who weighs 158 lb. A report in the literature stated that azithromycin lung concentrations are 1030% of azithromycin blood concentrations. Assume azithromycin has an elimination half-life of 53 hr, an absorption half-life of...
#1) While reviewing medication orders in a hospital, you encounter an order for tobramycin, an antibiotic, to be administered as intermittent intravenous infusions. Checking this order, you identify the following information: - The patient weighs 266 lbs - The physician ordered 5.2 mg/kg/day given in 6 divided doses - Each dose should be administered as an intermittent intravenous infusion - Each infusion should last 30 minutes - The technician has prepared a 150 mL small volume parenteral bag containing 9...
1. An IV bag contains 600mg of a drug in 200mL of NS the flow rate in ml/h and the dosage rate in mg/min. 10 B of a drug in 200mL of NS, and must infuse over 2 hours. Find 2. An IVPB bag containing 50 mg of drug in 100mL of solution must intus 2mg/min. If the infusion begins at 0800 h, when will it finish? of solution must infuse at the rate of 3. ANIVPB IS infusing at...
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