If 100 mg of a drug are administered intravenously, and the resultant drug plasma concentration is determined to be 2.5 ug/mL, calculate the apparent volume of distribution. The correct answer is 40 L. Please show how this question is solved.
ANSWER
* Apparent volume of distribution.
Formula
Volume of distribution (VD) = Drug mass / concentration.
Drug mass = 100 mg.
Concentration = 2.5 mcg / ml
VD = 100 / 2.5
= 40 L.
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