Therapeutic concentration range for theophylline is 10-20 mg/L. 1. Calculate Theophylline steady state concentration at a...
Therapeutic concentration range for theophylline is
10-20 mg/L.
1. Calculate Theophylline steady state concentration at a constant
infusion rate of 25 mg/ hr.
2. What will be infusion rate required to achieve therapeutic
steady state concentration of 15 mg/L?
NB
• Apparent volume of distribution for theophylline is 30L/hr
• Elmination rate constant is 0.1155 -hr.
Homework Answers
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Therapeutic concentration range for theophylline is
10-20 mg/L.
1. Calculate Theophylline steady state concentration at a...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
Hendeles and Weinberger further state an infusion of 0.85 mg/kg/hr of theophylline will produce an eventual...
Hendeles and Weinberger further state an infusion of 0.85 mg/kg/hr of theophylline will produce an eventual plasma theophylline concentration of 10 mcg/ml in children 1-9 years old (plasma concentrations, however, should be monitored after 12-24 hours to avoid toxicity). a) If Hendeles and Weinberger are correct about the Cpss of 10mcg/ml, what would be the K and t1/2 in this example child? (b) What infusion rate (Ro) of aminophylline should therefore be given to a 3-year-old. 15 kg child to...
can anyone help me solve this pharmokientics question Part 1 of 2 12. A steady-state plasma...
can anyone help me solve this pharmokientics question
Part 1 of 2 12. A steady-state plasma concentration of 25 mg/L v by IV infusion to healthy volunteers (average weight, 75 kg) at a rate of 7.5 mg/kg/hr for 6 hours. Calculate the total body clearance of this drug. A. 12.5 L/hr B. 22.5 L/hr C. 42.5 L/hr D. 62.5 L/hr was measured when a drug was given Part 2 of 2 13. (A steady-state plasma concentration of 25 mg/L by...
QUESTION4 A steady state concentration of 2 mg/L needs to be reached immediately in a patient....
QUESTION4 A steady state concentration of 2 mg/L needs to be reached immediately in a patient. The drug has a half-ife of 12 hours and a volume of distribution of 75 L. Calculate the loading dose in mg.
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Calculate the steady-state flow rate, Qe in m3/day, and concentration of lake effluent, ce in mg/L, for the following system. The lake is well-mixed with two streams that enter the lake. Evaporation takes place from the lake but because c is not volatile none of it evaporates. QvAP 200 m2/day CEVA,-0 mg/L Q1-8 m3/min 1 4 mg/L QE CE Lake Q2-12 L/s c2-50 mg/L
can anyone help me solve these pharmokientics questions 1 and 2 mu sog 1 A m...
can anyone help me solve these pharmokientics questions 1 and
2
mu sog 1 A m sd of bnuot zew o6t ybsete r6 gub to noidsinoonoo smzsi Part 1 of 3 nd A drug is to be administered by continuous IV infusion to a patient. The drug has a ke of 0.1 h-1 hours and a volume of distribution of 20 L. The desired therapeutic plasma concentration of the drug is 10 mg/L Calculate an appropriate loading dose.gm S o...
Drug-A has an half-life of 2.4 hours and a volume of distribution of 18L. Calculate the...
Drug-A has an half-life of 2.4 hours and a volume of distribution of 18L. Calculate the infusion rate necessary to mantain a steady state concentration of 12 mg/L in a 50 year old patient. O a 62.4 mg Ob. 520 mg C0.67 mgn O d. 43 mg
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please ahow all work What will be the steady-state effluent BOD concentration for a CSTR (complete...
please ahow all work
What will be the steady-state effluent BOD concentration for a CSTR (complete mix reactor with flows in and out, and no recycle) treating a wastewater with an initial BOD of 200 mg/L. The influent flow rate is 100 liters/day, and the reactor volume is 120 liters. Assume first order kinetics with a biodegradation rate constant of 0.5 day! Use the space provided below to show your calculations. mg/L Effluent BOD concentration
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
can anyone help me solve this pharmokientics question
Part 1 of 2 12. A steady-state plasma concentration of 25 mg/L v by IV infusion to healthy volunteers (average weight, 75 kg) at a rate of 7.5 mg/kg/hr for 6 hours. Calculate the total body clearance of this drug. A. 12.5 L/hr B. 22.5 L/hr C. 42.5 L/hr D. 62.5 L/hr was measured when a drug was given Part 2 of 2 13. (A steady-state plasma concentration of 25 mg/L by...
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Calculate the steady-state flow rate, Qe in m3/day, and concentration of lake effluent, ce in mg/L, for the following system. The lake is well-mixed with two streams that enter the lake. Evaporation takes place from the lake but because c is not volatile none of it evaporates. QvAP 200 m2/day CEVA,-0 mg/L Q1-8 m3/min 1 4 mg/L QE CE Lake Q2-12 L/s c2-50 mg/L
can anyone help me solve these pharmokientics questions 1 and
2
mu sog 1 A m sd of bnuot zew o6t ybsete r6 gub to noidsinoonoo smzsi Part 1 of 3 nd A drug is to be administered by continuous IV infusion to a patient. The drug has a ke of 0.1 h-1 hours and a volume of distribution of 20 L. The desired therapeutic plasma concentration of the drug is 10 mg/L Calculate an appropriate loading dose.gm S o...
Drug-A has an half-life of 2.4 hours and a volume of distribution of 18L. Calculate the infusion rate necessary to mantain a steady state concentration of 12 mg/L in a 50 year old patient. O a 62.4 mg Ob. 520 mg C0.67 mgn O d. 43 mg
please ahow all work
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