Question

Preparation #5: Formula (Reconstitution for IM injection per manufacturer): Ceftriaxone 250mg/mL IM injection Ceftriaxone Dry Powder for Injection 1-g vial Sterile Water for Injection According to the manufacturer's instructions, to achieve a concentration of 250- mg/mL, reconstitute the 1-gram vial with 3.6-mL of diluent (SWFI, NS,D5W,etc). Procedure: Perform all necessary calculations and gather equipment and supplies. (No Calculations for this procedure) Aseptically introduce containers and supplies into the PEC. • Carefully remove the plastic cap from each vial. Disinfect the rubber stopper of each vial with a 70% IPA swab. • Aseptically attach a 21 G needle to the 10-mL syringe. Withdraw the appropriate volume of SWFI from the SWFI vial. Inject the SWFI into the ceftriaxone dry powder for injection vial. Before inverting vial, carefully allow air to fill the syringe (volume approximate to the volume of SWFI injected into the vial). Withdraw the needle from the vial and recap the needle. Set needle and syringe aside but maintain contact of first air to critical sites. Dissolve the ceftriaxone dry powder for injection by agitating the vial. Use caution to maintain contact between first air and critical site of vial. Detach the 21 G needle and discard in appropriate sharps container. • Attach the second 21 G needle to the syringe. • Withdraw___mL from the reconstituted solution vial. Recap needle and detach from syringe. Discard needle in appropriate sharps container. • Attach a sterile syringe tip cap to the syringe. Return filled syringe and vials to tote for verification. Calculations: 1. What volume of the reconstituted solution will deliver a dose of 700-mg?

Answer 1

The constituted solution has a concentration of 250 mg/mL.

So 250 mg is present in 1 ml.

700 mg in = 1/250 * 700 = 2.8 mL.

2) The drug powder is 1 gram.

To make a concentration of 350 mg/mL,

350 mg in 1 mL.

1000 mg (1 g) in = 1/350 *1000 = 2.83 mL.

So 2.8 mL should be added.

350 mg in 1 mL.

700 mg in 1/350 * 700 = 2 mL